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Titolo:
HUMAN AND MURINE DERMIS CONTAIN DENDRITIC CELLS - ISOLATION BY MEANS OF A NOVEL METHOD AND PHENOTYPICAL AND FUNCTIONAL-CHARACTERIZATION
Autore:
LENZ A; HEINE M; SCHULER G; ROMANI N;
Indirizzi:
INNSBRUCK UNIV,DEPT DERMATOL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,DEPT DERMATOL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
The Journal of clinical investigation
fascicolo: 6, volume: 92, anno: 1993,
pagine: 2587 - 2596
SICI:
0021-9738(1993)92:6<2587:HAMDCD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL LANGERHANS CELLS; ANTIGEN-PRESENTING CELLS; NORMAL HUMAN-SKIN; COLONY-STIMULATING FACTOR; MONOCLONAL-ANTIBODY; ENDOTHELIAL-CELLS; PERIPHERAL-BLOOD; LYMPHOCYTES-T; INVITRO; SYSTEM;
Keywords:
ANTIGEN PRESENTING CELL; LANGERHANS CELL; DERMIS; DENDRITIC CELL; IMMUNOSTIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A. Lenz et al., "HUMAN AND MURINE DERMIS CONTAIN DENDRITIC CELLS - ISOLATION BY MEANS OF A NOVEL METHOD AND PHENOTYPICAL AND FUNCTIONAL-CHARACTERIZATION", The Journal of clinical investigation, 92(6), 1993, pp. 2587-2596

Abstract

Dendritic cells (DC) comprise a system of cells in lymphoid and nonlymphoid organs that are specialized to present antigens and to initiateprimary T cell responses. The Langerhans cell of the epidermis is used as a prototype for studies of DC in the skin. We have characterized a population of DC in human dermis, one of the first examples of thesecells in nonlymphoid organs other than epidermis. To identify their distinct functions and phenotype, we relied upon the preparation of enriched populations that emigrate from organ explants of dermis. The dermal cells have the following key features of mature DC: (a) sheet-likeprocesses, or veils, that are constantly moving; (b) very high levelsof surface MHC products; (c) absence of markers for macrophages, lymphocytes, and endothelium; (d) substantial expression of adhesion/costimulatory molecules such as CD11/CD18, CD54(ICAM-1), B7/BB1, CD40; and (e) powerful stimulatory function for resting T cells. Dermal DC are fully comparable to epidermis-derived DC, except for the lack of Birbeck granules, lower levels of CD1a, and higher levels of CD36. DC were also detected in explants of mouse dermis. We conclude that cutaneous DC include both epidermal and dermal components, and suggest that otherhuman nonlymphoid tissues may also serve as sources of typical immunostimulatory DC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:06:40