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Titolo:
ANDROGEN REGULATION OF ADRENOCORTICOTROPIN AND CORTICOSTERONE SECRETION IN THE MALE-RAT FOLLOWING NOVELTY AND FOOT SHOCK STRESSORS
Autore:
HANDA RJ; NUNLEY KM; LORENS SA; LOUIE JP; MCGIVERN RF; BOLLNOW MR;
Indirizzi:
LOYOLA UNIV,STRITCH SCH MED,DEPT CELL BIOL,2160 S 1ST AVE MAYWOOD IL 60153 LOYOLA UNIV,STRITCH SCH MED,DEPT NEUROBIOL & ANAT MAYWOOD IL 60153 LOYOLA UNIV,STRITCH SCH MED,DEPT PHARMACOL MAYWOOD IL 60153 SAN DIEGO STATE UNIV,DEPT PSYCHOL SAN DIEGO CA 92182
Titolo Testata:
Physiology & behavior
fascicolo: 1, volume: 55, anno: 1994,
pagine: 117 - 124
SICI:
0031-9384(1994)55:1<117:AROAAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL RESPONSE; SEX-DIFFERENCES; GONADAL-HORMONES; MESSENGER-RNA; ETHER STRESS; FEMALE RATS; BRAIN; RECEPTORS; NEURONS;
Keywords:
ANDROGEN; ACTH; CORTICOSTERONE; TESTOSTERONE; DIHYDROTESTOSTERONE; ESTROGEN; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; CRH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Handa et al., "ANDROGEN REGULATION OF ADRENOCORTICOTROPIN AND CORTICOSTERONE SECRETION IN THE MALE-RAT FOLLOWING NOVELTY AND FOOT SHOCK STRESSORS", Physiology & behavior, 55(1), 1994, pp. 117-124

Abstract

To examine mechanisms responsible for sex differences in hypothalamo-pituitary-adrenal (HPA) axis responsiveness to stress, we studied the role of androgens in the regulation of the adrenocorticotropin (ACTH) and corticosterone (CORT) responses to foot shock and novelty stressors in gonadectomized (GDX) or intact male F344 rats. Foot shock or exposure to a novel open field increased plasma ACTH and CORT, which was significantly greater in GDX vs. intacts. Testosterone (T) or dihydrotestosterone propionate (DHT) treatment of GDX animals returned poststress levels of ACTH and CORT to intact levels. Estrogen treatment of GDXmales further increased poststress CORT secretion above GDX levels. There was no difference in the ACTH response of anterior pituitaries from intact, GDX, and GDX+DHT animals to CRF using an in vitro perifusion system. There were no differences in betamax or binding affinity of type I or 11 CORT receptors in the hypothalamus or hippocampus of intact, GDX, or GDX+DHT groups. These data demonstrate an effect of GDX onhormonal indices of stress. The increased response in GDX rats appears to be due to the release from androgen receptor mediated inhibition of the HPA axis. This inhibition by androgen is not due to changes in anterior pituitary sensitivity to CRH, nor to changes in type I or type II corticosteroid receptor concentrations.

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Documento generato il 28/09/20 alle ore 15:24:48