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Titolo:
OPIOID-DOPAMINERGIC INTERACTIONS IN PRIMARY EMPTY SELLA
Autore:
MANCINI A; CONTE G; FIUMARA C; FABRIZI ML; IACONA T; ZUPPI P; COLOSIMO C; DEMARINIS L;
Indirizzi:
LARGO GEMELLI 8 I-00168 ROME ITALY CATHOLIC UNIV SACRED HEART,SCH MED,INST ENDOCRINOL I-00168 ROME ITALY CATHOLIC UNIV SACRED HEART,SCH MED,INST RADIOL I-00168 ROME ITALY
Titolo Testata:
Experimental and clinical endocrinology
fascicolo: 5, volume: 101, anno: 1993,
pagine: 277 - 282
SICI:
0232-7384(1993)101:5<277:OIIPES>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-FUNCTION; INTRACRANIAL-PRESSURE; PROLACTINOMA PATIENTS; HORMONE-SECRETION; RELEASE; METOCLOPRAMIDE; HYPOTHALAMUS; TONE;
Keywords:
EMPTY SELLA; OPIOIDS; DOPAMINE; PITUITARY HORMONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Mancini et al., "OPIOID-DOPAMINERGIC INTERACTIONS IN PRIMARY EMPTY SELLA", Experimental and clinical endocrinology, 101(5), 1993, pp. 277-282

Abstract

Previous studies have indicated different abnormalities of PRL secretion in patients with primary empty sella (PES). Since it is known thatendogenous opiates and dopamine interact in modulating PRL secretion,we have studied the effect of an opiate receptor blockade (with Naloxone, NAL, 1.6 mg/h as a continuous infusion) on anterior pituitary hormones and on PRL responsiveness to metoclopramide (MCP), in 10 premenopausal normoprolactinemic patients with PES, studied in follicular phase, in order to investigate neurotransmitter abnormalities present in such a syndrome. NAL failed to significantly affect LH and FSH basal levels; on the contrary, slight but significant increases in PRL and GHsecretion were observed. NAL partially blunted the PRL responsivenessto the dopaminergic blockade, which was very marked when tested afterMCP alone. These data confirm that the modulation of anterior pituitary hormone secretion is different in PES patients, when compared with normal subjects. The infusion of NAL induced a ''paradoxical'' increase in hormones (PRL and GH) which are normally stimulated by endogenousopiates; but, on the other side, it blocked the marked PRL responsiveness to the dopaminergic blockade, which is characteristic of PES syndrome. This phenomenon seems to indicate that the relationships betweendopaminergic and opiatergic neurons could be modified by the neuroanatomic alteration which is present in this complex syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:40:22