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Titolo:
DIFFERENTIATION OF CLARA CELLS AND PNEUMOCYTES OF THE RAT BY MEANS OFENZYMEHISTOCHEMISTRY AND IMMUNOHISTOCHEMISTRY
Autore:
KUDO S;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT ANAT MAEBASHI GUNMA 371 JAPAN
Titolo Testata:
The Anatomical record
fascicolo: 1, volume: 238, anno: 1994,
pagine: 49 - 56
SICI:
0003-276X(1994)238:1<49:DOCCAP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZINC SUPEROXIDE-DISMUTASE; INTERSTITIAL CELL; RENAL DIPEPTIDASE; RABBIT LUNG; PULMONARY; IMMUNOLOCALIZATION; CYTOCHROME-P-450; ANTIBIOTICS; HEPATOCYTES; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S. Kudo, "DIFFERENTIATION OF CLARA CELLS AND PNEUMOCYTES OF THE RAT BY MEANS OFENZYMEHISTOCHEMISTRY AND IMMUNOHISTOCHEMISTRY", The Anatomical record, 238(1), 1994, pp. 49-56

Abstract

Localization of non-specific esterases, Cu-Zn superoxide dismutase and dehydropeptidase-I, in rat lung was investigated enzyme-cytochemically or immunohistochemically. Esterase was demonstrated in Clara cells,type II pneumocytes, and septal cells (or vitamin A-storing lung cells), to a somewhat lesser extent in type I pneumocytes and ciliated epithelial cells of the bronchioles, and to a minor extent in interstitial fibroblasts of the alveolar septum. Large amounts of esterase reaction product were deposited in the rough endoplasmic reticulum and the nuclear envelope in Clara cells, type II pneumocytes, and septal cells,in addition to smaller amounts in other organelles. No reaction product was found in macrophages (histiocytes) in alveolar septi and alveolar macrophages, except for the primary lysosomes or phagolysosomes andtrace amounts in the Gels vesicles, and none in endothelial cells of alveolar blood capillaries, except for primary lysosomes. Immunolocalization of Cu-Zn superoxide dismutase was generally limited to a particular area of Clara cells. A constriction occurred in the apical cytoplasm of Clara cells between an immunoreactive dome-like protrusion and the non-immunoreactive cytoplasm of the supranuclear area, and the dome-like protrusion appeared to be pinched off in a ball-like or oval form. Immunolocalization of dehydropeptidase-I was demonstrated in a dome-like protrusion or supranuclear area of Clara cells or throughout the cytoplasm and in the surface plasma membrane of mesothelial cells. The presence of these enzymes in Clara cells suggests a contribution tothe detoxification system of the lung, together with cytochrome p-450-dependent monooxygenase systems. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:27:14