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Titolo:
2 NEUROTROPIC VIRUSES, HERPES-SIMPLEX VIRUS TYPE-1 AND MOUSE HEPATITIS-VIRUS, SPREAD ALONG DIFFERENT NEURAL PATHWAYS FROM THE MAIN OLFACTORY-BULB
Autore:
BARNETT EM; CASSELL MD; PERLMAN S;
Indirizzi:
UNIV IOWA,COLL MED,NEUROSCI PROGRAM IOWA CITY IA 52242 UNIV IOWA,COLL MED,NEUROSCI PROGRAM IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT ANAT IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT PEDIAT IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT MICROBIOL IOWA CITY IA 52242
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 57, anno: 1993,
pagine: 1007 - 1025
SICI:
0306-4522(1993)57:4<1007:2NVHVT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; MURINE CORONAVIRUS JHM; CENTRAL-NERVOUS-SYSTEM; EFFERENT CONNECTIONS; HORSERADISH-PEROXIDASE; PARABRACHIAL NUCLEUS; ALZHEIMERS-DISEASE; TRANSNEURONAL TRANSPORT; RETROGRADE TRANSPORT; SUBTHALAMIC NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Barnett et al., "2 NEUROTROPIC VIRUSES, HERPES-SIMPLEX VIRUS TYPE-1 AND MOUSE HEPATITIS-VIRUS, SPREAD ALONG DIFFERENT NEURAL PATHWAYS FROM THE MAIN OLFACTORY-BULB", Neuroscience, 57(4), 1993, pp. 1007-1025

Abstract

Several neurotropic viruses enter the brain after peripheral inoculation and spread transneuronally along pathways known to be connected tothe initial site of entry. In this study, the pathways utilized by two such viruses, herpes simplex virus type 1 and mouse hepatitis virus strain JHM, were compared using in situ hybridization following inoculation into either the nasal cavity or the main olfactory bulb of the mouse. The results indicate that both viruses spread to infect a uniqueand only partially overlapping set of connections of the main olfactory bulb. Both quantitative and qualitative differences were observed in the patterns of infection of known primary and secondary main olfactory bulb connections. Using immunohistochemistry for tyrosine hydroxylase combined with in situ hybridization, it was shown that only herpessimplex virus infected noradrenergic neurons in the locus coeruleus. In contrast, both viruses infected dopaminergic neurons in the ventraltegmental area, although mouse hepatitis virus produced a more widespread infection in the A10 group, as well as infecting A8 and A9. The results suggest that differential virus uptake in specific neurotransmitter systems contributes to the pattern of viral spread, although other factors, such as differences in access to particular synapses on infected cells and differences in the distribution of the cellular receptor for the two viruses, are also likely to be important. The data showthat neural tracing with different viruses may define unique neural pathways from a site of inoculation. The data also demonstrate that twoviruses can enter the brain via the olfactory system and localize to different structures, suggesting that neurological diseases involving disparate regions of the brain could be caused by different viruses, even if entry occurred at a common site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:49:29