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Titolo:
HEPATOTOXICITY OF PIPERONYL BUTOXIDE IN MALE F344 RATS
Autore:
FUJITANI T; TADA Y; YONEYAMA M;
Indirizzi:
TOKYO METROPOLITAN RES LAB PUBL HLTH,DEPT TOXICOL,SHINJUKU KU,3-24-1 HYAKUNICHO TOKYO 169 JAPAN
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 84, anno: 1993,
pagine: 171 - 183
SICI:
0300-483X(1993)84:1-3<171:HOPBIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
HEPATOTOXICITY; PIPERONYL BUTOXIDE; PESTICIDE SYNERGIST; RATS; SUBACUTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Fujitani et al., "HEPATOTOXICITY OF PIPERONYL BUTOXIDE IN MALE F344 RATS", Toxicology, 84(1-3), 1993, pp. 171-183

Abstract

Male F344 rats were given 0, 0.6, 1.2 or 2.4% of piperonyl butoxide in the diet. At 1, 2, 4 or 12 weeks after the beginning of the experiment, liver and kidney weight and serum clinical parameters were determined and livers and kidneys were examined with light microscopy. From 1or 2-12 weeks, distinct increase of liver weight, changes in serum clinical parameters for liver damage, oval cell proliferation, bile ducthyperplasia, single cell necrosis, enlarged and vacuolated hepatocytes, enlarged nuclei and anisonucleosis were seen in treated rats. From 4-12 weeks, cell infiltration, focal necrosis, multinucleated hepatocytes and prominent nucleoli of hepatocytes were seen in treated rats. At 12 weeks microgranulomas were seen in treated rats. Especially in rats of the 2.4% group at 12 weeks, severe enlargement of hepatocytes, severe enlargement of nuclei and multinucleated hepatocyte were seen, suggesting preneoplastic alteration. Relative kidney weights and serum urea nitrogen levels were increased in treated rats from 1 or 2-12 weeks and at 12 weeks, atrophy of proximal tubules, dilation of tubules, cell infiltration, fibrosis and accumulation of yellow-brown pigment in the proximal tubular cells were seen.

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Documento generato il 25/01/20 alle ore 18:46:51