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Titolo:
ELECTROPHYSIOLOGICAL IDENTIFICATION OF HORIZONTAL SYNAPTIC CONNECTIONS IN RAT VISUAL-CORTEX IN-VITRO
Autore:
MURAKOSHI T; GUO JZ; ICHINOSE T;
Indirizzi:
TOKYO MED & DENT UNIV,FAC MED,DEPT PHARMACOL,BUNKYO KU,1-5-45 YUSHIMATOKYO 113 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT ANESTHESIOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 163, anno: 1993,
pagine: 211 - 214
SICI:
0304-3940(1993)163:2<211:EIOHSC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-CORRELATION; ORGANIZATION; NEURONS; CAT; SPECIFICITY;
Keywords:
HORIZONTAL CONNECTION; INTRINSIC CONNECTION; RAT; VISUAL CORTEX; SYNAPTIC TRANSMISSION; GABA(B) RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
T. Murakoshi et al., "ELECTROPHYSIOLOGICAL IDENTIFICATION OF HORIZONTAL SYNAPTIC CONNECTIONS IN RAT VISUAL-CORTEX IN-VITRO", Neuroscience letters, 163(2), 1993, pp. 211-214

Abstract

The presence of intrinsic horizontal synaptic connections in rat visual cortex was explored electrophysiologically using in vitro slice preparations. Intracellular recordings were made from pyramidal neurons located in the superficial and deep layers. Electrical stimulation at the gray matter in the same or different layers but 0.8-2.7 mm apart from the recording site evoked compound synaptic potentials composed of excitatory and inhibitory postsynaptic potentials of fast and slow time courses. Glutamate blockers, DNQX (5 mu M) and kynurenate (2 mM) reduced the excitatory postsynaptic potential (EPSP), and GABA(B) receptor antagonist, phaclofen (0.5 mM), abolished the inhibitory postsynaptic potential of the slow time course. EPSP of the fast time course followed 20 Hz repetitive stimulation in the medium of high Ca2+ (6.0 mM) and Mg2+ (4.0 mM) concentration, suggesting that this fast EPSP was monosynaptic. Conduction velocity of the fibers mediating the monosynaptic EPSP was estimated to be 0.15-0.55 m/s. These results provide physiological evidence for the horizontal synaptic connections in the rat visual cortex, which had been previously suggested by morphology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:27:17