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Titolo:
MLS-1 AND MLS-2 SUPERANTIGENS DO NOT CONTROL SUSCEPTIBILITY TO COLLAGEN-INDUCED ARTHRITIS IN H-I AND H-II MICE
Autore:
ROGER T; BOUDALY S; COUDERC J; SEMAN M;
Indirizzi:
UNIV PARIS 07,IMMUNODIFFERANCIAT LAB,TOUR 54,BP 7124,2 PL JUSSIEU F-75251 PARIS 05 FRANCE INST CURIE,UNITE IMMUNOGENET PARIS FRANCE
Titolo Testata:
Immunology
fascicolo: 4, volume: 80, anno: 1993,
pagine: 661 - 663
SICI:
0019-2805(1993)80:4<661:MAMSDN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOZZI MICE; MOUSE STRAIN; T-CELLS; BETA; DELETION; GENES; POLYMORPHISM; INVOLVEMENT; H-2Q; C5;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T. Roger et al., "MLS-1 AND MLS-2 SUPERANTIGENS DO NOT CONTROL SUSCEPTIBILITY TO COLLAGEN-INDUCED ARTHRITIS IN H-I AND H-II MICE", Immunology, 80(4), 1993, pp. 661-663

Abstract

The H-I mouse line is sensitive to collagen-induced arthritis (CIA), whereas H-II is refractory, although both express the H-2(q) permissive haplotype. The two lines also share the same T-cell receptor (TcR) gene haplotypes for alpha and beta chains. The distribution of mouse mammary tumour viruses (MMTV), which encode endogenous superantigens (SAg) such as minor leucocyte-stimulating antigens (Mls) known to modulate the available TcR-V beta repertoire, was investigated in the two lines. Mls-1 is present in H-I-susceptible mice, while Mls-2 and Mls-2-like SAg are absent in both lines. This suggests that Mls antigens play no significant role in the resistance to CIA. Moreover, H-I and H-II exhibit close V beta gene usage as assessed by fluorescence staining with 11 V beta-specific monoclonal antibodies (mAb). These results indicate that mechanisms other than clonal deletion based on V beta expression and induced by SAg are involved in the resistance of H-2(q)-positive mice to experimental arthritis. Yet, a slightly reduced level of V beta 5(+) T cells is observed in H-II animals which might correlate with the presence of Mtv-6 and Mtv-9 proviruses.

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Documento generato il 27/11/20 alle ore 07:27:37