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Titolo:
RENAL EFFECTS OF RILMENIDINE IN VOLUME-LOADED ANESTHETIZED DOGS
Autore:
EVANS RG; SHWETA A; MALPAS SC; FITZGERALD SM; ANDERSON WP;
Indirizzi:
MONASH UNIV,DEPT PHYSIOL CLAYTON VIC 3168 AUSTRALIA BAKER MED RES INST,EMILY EE STEWART RENAL LAB PRAHRAN VIC 3181 AUSTRALIA
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 1, volume: 24, anno: 1997,
pagine: 64 - 67
SICI:
0305-1870(1997)24:1<64:REORIV>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; CONSCIOUS DOGS; NITRIC-OXIDE; MOXONIDINE; EXCRETION; GUANABENZ; EXPANSION; AGONIST; SITES;
Keywords:
ALPHA-ADRENOCEPTORS; DOG; IMIDAZOLINE RECEPTOR; KIDNEY; PENTOBARBITAL ANESTHESIA; PLASMA VOLUME EXPANSION; RENAL BLOOD FLOW; RILMENIDINE SODIUM EXCRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Evans et al., "RENAL EFFECTS OF RILMENIDINE IN VOLUME-LOADED ANESTHETIZED DOGS", Clinical and experimental pharmacology and physiology, 24(1), 1997, pp. 64-67

Abstract

1. In anaesthetized, fluid expanded rats rilmenidine has diuretic andnatriuretic effects. There is strong evidence that the natriuresis ismediated by putative imidazoline receptors. In contrast, in consciouseuvolaemic dogs rilmenidine has a diuretic effect that is entirely attributable to activation of alpha(2)-adrenoceptors, but no natriureticeffect. To determine whether the effects of rilmenidine are truly species dependent, or merely dependent upon the influences of anaesthesiaand volume status, we tested the effects of rilmenidine in pentobarbitone anaesthetized, volume-loaded dogs. 2. The effects of rilmenidine in anaesthetized, volume-loaded dogs were similar to those found in conscious euvolaemic dogs, Compared with vehicle treatment, levels of glomerular filtration rate, urine flow and haematocrit were increased following rilmenidine treatment. No effect of rilmenidine on sodium excretion was observed. 3. We conclude that the renal responses to rilmenidine in dogs are largely unaffected by anaesthesia and plasma volume status, In particular, the natriuretic effect seen in rats was not observed. We conclude that putative imidazoline receptors do not have a major influence on sodium excretion in dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:02:17