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Titolo:
EVALUATION OF MYOCARDIAL ENERGY STATUS IN-VIVO BY NMR-SPECTROSCOPY
Autore:
SEYMOUR AML;
Indirizzi:
HAREFIELD HOSP,NATL HEART & LUNG INST,DEPT CARDIOTHORAC SURG,MAGNET RESONANCE SPECT GRP HAREFIELD UB9 6JH MIDDX ENGLAND
Titolo Testata:
Basic research in cardiology
fascicolo: 5, volume: 88, anno: 1993,
pagine: 385 - 395
SICI:
0300-8428(1993)88:5<385:EOMESI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; SKELETAL-MUSCLE METABOLISM; TRICARBOXYLIC-ACID CYCLE; CORONARY-ARTERY DISEASE; HEART-FAILURE; PHOSPHATE-METABOLISM; RAT-HEART; P-31; RESPIRATION; C-13;
Keywords:
NMR; P-31; ENERGY METABOLISM; ATP TURNOVER; METABOLIC FLUXES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A.M.L. Seymour, "EVALUATION OF MYOCARDIAL ENERGY STATUS IN-VIVO BY NMR-SPECTROSCOPY", Basic research in cardiology, 88(5), 1993, pp. 385-395

Abstract

NMR spectroscopy is a powerful and non-invasive technique with which to study cardiac energy metabolism in vivo. This method makes use of the ''spin'' properties of certain atomic nuclei. The naturally occurring phosphorus nucleus (P-31) is visible by NMR and phosphorus-31 NMR spectra contain signals from the major components of energy metabolism. In vivo, the phosphocreatine to ATP ratio (PCr/ATP) is used as an index of the energy status and viability of the myocardium. However, it is the response of this metabolic index to differing physiological and pharmacological stresses that has helped to elucidate the mechanisms that regulate cellular respiration and to highlight abnormalities in heart failure. As there are many technical difficulties involved with cardiac NMR, 31-phosphorus studies of skeletal muscle have provided an indirect way of studying abnormalities in myocardial metabolism in vivo. One of the unique features of NMR is that it permits in vivo measurements of fluxes through key enzymes in energy metabolism using magnetization transfer. Determination of the rates of energy transfer throughthe creatine kinase reaction and energy turnover in vivo will providenew insights into the control of energy metabolism in health and disease. Alternatively, carbon-13 NMR can be used to measure fluxes through the different metabolic pathways of synthesis and catabolism following administration of selectively labelled carbon-13 substrates. In conclusion, the non-invasive and versatile nature of NMR spectroscopy makes it an ideal method to assess and evaluate energy metabolism in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:56:17