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Titolo:
CRITICAL ISSUES IN THE TREATMENT OF EPILEPSY
Autore:
HOLMES GL;
Indirizzi:
CHILDRENS HOSP,CLIN NEUROPHYSIOL LAB,HUNNEWELL 2,300 LONGWOOD AVE BOSTON MA 02115 CHILDRENS HOSP,EPILEPSY PROGRAM BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 00000
Titolo Testata:
American journal of hospital pharmacy
fascicolo: 12, volume: 50, anno: 1993, supplemento:, 5
pagine: 190000005 - 190000016
SICI:
0002-9289(1993)50:12<190000005:CIITTO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE MYOCLONIC EPILEPSY; 1ST UNPROVOKED SEIZURE; COMPLEX-PARTIAL SEIZURES; ACID HEPATIC FATALITIES; TONIC-CLONIC SEIZURES; VALPROIC ACID; ANTIEPILEPTIC DRUGS; FOLLOW-UP; CARBAMAZEPINE THERAPY; GENERALIZED EPILEPSY;
Keywords:
ANTICONVULSANTS; BLOOD LEVELS; EPILEPSY; TOXICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
112
Recensione:
Indirizzi per estratti:
Citazione:
G.L. Holmes, "CRITICAL ISSUES IN THE TREATMENT OF EPILEPSY", American journal of hospital pharmacy, 50(12), 1993, pp. 190000005-190000016

Abstract

Classification of seizure types and evaluation and treatment of seizure disorders are discussed. Once the diagnosis of a seizure is made, the seizure type must be identified; this will help in determining the treatment. In partial seizures, the electrical discharge occurs focally, while generalized seizures involve both cerebral hemispheres simultaneously. Magnetic resonance imaging is the preferred test in the evaluation of patients with seizures, although computed tomography and electroencephalography can also be helpful. Selection of an antiepilepticdrug (AED) is based on efficacy, toxicity, and, to a lesser degree, cost. Adverse reactions occur in up to 50% of patients. First-line AEDsinclude carbamazepine, ethosuximide, phenobarbital, primidone, phenytoin, and valproic acid. Serum AED concentrations can be helpful in managing patients with epilepsy. The serum concentrations required to control seizures or resulting in toxicity may vary among patients. Most seizures are manageable with oral AEDs. Medications of choice in statusepilepticus include diazepam, lorazepam, phenytoin, and phenobarbital. The key to treating epilepsy is correct diagnosis of the seizure type and, when possible, the type of epilepsy. Most patients with epilepsy respond to one of the first-line AEDs; second-line agents may be useful in patients who do not respond to one or a combination of the first-line agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:56:16