Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HALOTHANE PREVENTS POSTISCHEMIC PRODUCTION OF HYDROXYL RADICALS IN THE CANINE HEART
Autore:
GLANTZ L; GINOSAR Y; CHEVION M; GOZAL Y; ELAMI A; NAVOT N; KITROSSKY N; DRENGER B;
Indirizzi:
HADASSAH UNIV HOSP,DEPT ANESTHESIOL & CRIT CARE MED,POB 12000 IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT ANESTHESIOL & CRIT CARE MED IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,SCH MED IL-91010 JERUSALEM ISRAEL
Titolo Testata:
Anesthesiology
fascicolo: 2, volume: 86, anno: 1997,
pagine: 440 - 447
SICI:
0003-3022(1997)86:2<440:HPPPOH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-ISCHEMIA; VOLATILE ANESTHETICS; REPERFUSION INJURY; ENDOTHELIAL-CELLS; CALCIUM CHANNELS; ACTIVATION; DYSFUNCTION; SARCOLEMMA; SALICYLATE; GENERATION;
Keywords:
ANESTHETICS, VOLATILE, HALOTHANE; ANIMAL, DOG; DIHYDROXYBENZOIC ACID, HIGH-PRESSURE LIQUID CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; FREE RADICALS, HYDROXYL RADICALS; HEART, CORONARY CIRCULATION, OCCLUSION, REGIONAL ISCHEMIA; HEART, STUNNED MYOCARDIUM, POSTISCHEMIC, REPERFUSION; SALICYLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
L. Glantz et al., "HALOTHANE PREVENTS POSTISCHEMIC PRODUCTION OF HYDROXYL RADICALS IN THE CANINE HEART", Anesthesiology, 86(2), 1997, pp. 440-447

Abstract

Background: Recent studies indicate that during regional myocardial ischemia and subsequent reperfusion, volatile anesthetics may provide protection against free radical-related injury. The effect of halothaneon free radical production during ischemia and reperfusion, in the canine heart, was investigated. The level of hydroxyl radical ((OH)-O-.)-mediated conversion of salicylate to its dehydroxybenzoate derivatives (2,3-DHBA and 2,5-DHBA) was monitored. Methods: Under general anesthesia, the heart was exposed through median sternotomy. Salicylate (100mg/kg given intravenously) was administered 30 min before left anterior descending artery occlusion. Six dogs were studied using inhaled halothane (1.6%) 10 min before and during the 10-min ischemic period, followed by 50 min of reperfusion, and then they were compared with seven other dogs used as controls. Blood concentrations of salicylate, 2,3-DHBA and 2,5-DHBA, K+, lactate, oxygen content, and pH were monitored. Results: An acute increase in the normalized concentrations of 2,3-DHBA and 2,5-DHBA was observed in the control animals during reperfusion. In contrast, halothane inhalation completely inhibited the production of both metabolites (P < 0.02), but 2,5-DHBA concentrations in the halothane-treated group were even less than the basal level (P < 0.05). The increase in lactate concentrations in the experimental animals was significantly less than that of controls (P < 0.05) and followed the same time-dependent pattern as the changes in K+ and pH. Halothane significantly decreased (P < 0.0001) the difference in oxygen content between coronary sinus and aortic root blood, suggesting decreased oxygen utilization during reperfusion. Conclusions: Halothane completely inhibited the production of (OH)-O-., and its administration may protect the heart from the deleterious effect of oxygen-derived reactive species, with attenuation of the metabolic response to ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:08:21