Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ISOLATION AND CHARACTERIZATION OF A CELL-LINE FROM THE EPITHELIAL-CELLS OF THE HUMAN FETAL PANCREAS
Autore:
WANG S; BEATTIE GM; MALLY MI; CIRULLI V; ITKINANSARI P; LOPEZ AD; HAYEK A; LEVINE F;
Indirizzi:
UNIV CALIF SAN DIEGO,SCH MED,DEPT PEDIAT,CTR GENET MOL,9894 GENESEE AVE LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,SCH MED,DEPT PEDIAT,CTR GENET MOL LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,SCH MED,WHITTIER INST DIABET,DEPT PEDIAT LA JOLLA CA 92037
Titolo Testata:
Cell transplantation
fascicolo: 1, volume: 6, anno: 1997,
pagine: 59 - 67
SICI:
0963-6897(1997)6:1<59:IACOAC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CELLS; ADHESION MOLECULE; RAT PANCREAS; INSULIN GENE; ISLET CELLS; EXPRESSION; GLUCOSE; DIFFERENTIATION; AGGREGATION; PRECURSORS;
Keywords:
TRANSFORMATION; HUMAN FETAL PANCREAS; CELL LINE; RETROVIRAL VECTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
S. Wang et al., "ISOLATION AND CHARACTERIZATION OF A CELL-LINE FROM THE EPITHELIAL-CELLS OF THE HUMAN FETAL PANCREAS", Cell transplantation, 6(1), 1997, pp. 59-67

Abstract

Pancreatic cell lines are useful for basic studies of pancreatic biology and for possible application to cell transplantation therapies fordiabetes. A retroviral vector expressing simian virus 40 (SV40) T antigen and H-ras(val12) was used to infect a monolayer culture of epithelial cells from an 18-wk human fetal pancreas, Infected cells gave rise to a clonal epithelial cell line, designated TRM-1. This cell line expresses epithelial markers as well as glut2 and small amounts of insulin and glucagon, TRM-1 is the first cell line to be generated from the human fetal pancreas and also the first cell line derived directly from the fetal pancreas of any species. The approach that we have used to develop TRM-1 should be applicable to isolating cell lines from other stages of human pancreatic development. Copyright (C) 1997 ElsevierScience, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:00:34