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Titolo:
ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS
Autore:
BOREN T; FALK P; ROTH KA; LARSON G; NORMARK S;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110 GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT CLIN CHEM S-41345 GOTHENBURG SWEDEN WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PHARMACOL ST LOUIS MO 63110
Titolo Testata:
Science
fascicolo: 5141, volume: 262, anno: 1993,
pagine: 1892 - 1895
SICI:
0036-8075(1993)262:5141<1892:AOHTHG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOLIPID RECEPTORS; ULCER DISEASE; BACTERIA; GLYCOSPHINGOLIPIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Boren et al., "ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS", Science, 262(5141), 1993, pp. 1892-1895

Abstract

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Le(b) antigen or antibodies to theLe(b) antigen inhibited bacterial binding. Gastric tissue lacking Le(b) expression did not bind H. pylori. Bacteria did not bind to Le(b) antigen substituted with a terminal GalNAcalpha1-3 residue (blood groupA determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:24:07