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Titolo:
IN-VITRO ACTIVITY OF NOVOBIOCIN AGAINST MULTIRESISTANT STRAINS OF ENTEROCOCCUS-FAECIUM
Autore:
FRENCH P; VENUTI E; FRAIMOW HS;
Indirizzi:
JEFFERSON MED COLL,DEPT MED,DIV INFECT DIS,DORRANCE H HAMILTON LABS PHILADELPHIA PA 19107 JEFFERSON MED COLL,DEPT MED,DIV INFECT DIS,DORRANCE H HAMILTON LABS PHILADELPHIA PA 19107
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 12, volume: 37, anno: 1993,
pagine: 2736 - 2739
SICI:
0066-4804(1993)37:12<2736:IAONAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT STAPHYLOCOCCUS-AUREUS; COMBINATION; VANCOMYCIN; RIFAMPIN; STATE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. French et al., "IN-VITRO ACTIVITY OF NOVOBIOCIN AGAINST MULTIRESISTANT STRAINS OF ENTEROCOCCUS-FAECIUM", Antimicrobial agents and chemotherapy, 37(12), 1993, pp. 2736-2739

Abstract

Sixty strains of vancomycin- and ampicillin-resistant Enterococcus faecium were evaluated for their susceptibilities to novobiocin in vitro. In Mueller-Hinton broth, novobiocin inhibited all strains when it was used at a concentration of less than or equal to 2 mu g/ml and 40 of60 strains when it was used at a concentration of less than or equal to 0.5 mu g/ml. MICs were 8- to 16-fold higher in 50% serum. Novobiocin alone resulted in 2-log-unit killing at 24 h. Combinations of novobiocin and a fluoroquinolone (either ciprofloxacin or ofloxacin) were additive and bactericidal for quinolone-susceptible strains in either broth or 50% serum. Gentamicin did not affect novobiocin activity, and rifampin and doxycycline were antagonistic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:46:17