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Titolo:
MODULATION OF [H-3] MAZINDOL BINDING-SITES IN RAT STRIATUM BY DOPAMINERGIC AGENTS
Autore:
IKAWA K; WATANABE A; KANENO S; TORU M;
Indirizzi:
TOKYO METROPOLITAN HIROO GEN HOSP,DEPT NEUROPSYCHIAT,2-34-10 EBISU,SHIBUYA KU TOKYO 150 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT NEUROPSYCHIAT,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 250, anno: 1993,
pagine: 261 - 266
SICI:
0014-2999(1993)250:2<261:MO[MBI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOREPINEPHRINE UPTAKE SITES; HUMAN-BRAIN TISSUE; DESIPRAMINE BINDING; NEURONAL DOPAMINE; CORPUS STRIATUM; TRANSPORTER; AUTORADIOGRAPHY; NOMIFENSINE; EXPRESSION; MEMBRANES;
Keywords:
[H-3]MAZINDOL; DOPAMINE UPTAKE SITE; DOPAMINE TURNOVER; L-DOPA(L-3,4-DIHYDROXYPHENYLALANINE); ALPHA-METHYL-P-TYROSINE; GBR-12909;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
K. Ikawa et al., "MODULATION OF [H-3] MAZINDOL BINDING-SITES IN RAT STRIATUM BY DOPAMINERGIC AGENTS", European journal of pharmacology, 250(2), 1993, pp. 261-266

Abstract

This study was undertaken to examine whether repeated alteration of dopamine turnover influences the function of dopamine uptake sites. In the first experiment, rats were repeatedly injected intraperitoneally with L-3,4-dihydroxyphenylalanine (L-DOPA), alpha-methyl-p-tyrosine orphenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) once daily for 14 days. An increase in the number of [H-3]mazindoI binding sites in the striatum was seen with L-DOPA and GBR 12909. A decrease was seen with alpha-methyl-p-tyrosine. In the second experiment, the effect of a single treatment with the same drugs was investigated and no change in the number and affinity of [H-3]mazindol binding sites was found. These results indicate that the number of dopamine uptake sites is modulated by persistent changes in dopamine turnover, and that repeated treatment with a selective dopamine uptake inhibitor, GBR 12909, increases their number.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:53:19