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Titolo:
AN ANIMAL-MODEL OF CHRONIC ISCHEMIC NEUROPATHY WITH PROLIFERATIVE CHANGES OF NERVE MICROVESSEL WALL
Autore:
YASUDA H; HISANAGA T; MAEDA K; KAWABATA T; TAKIGAWA T; TERADA M; KIKKAWA R; SHIGETA Y;
Indirizzi:
SHIGA UNIV MED SCI,DEPT MED 3 OTSU SHIGA 52021 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 120, anno: 1993,
pagine: 64 - 70
SICI:
0022-510X(1993)120:1<64:AAOCIN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN DIABETIC NEUROPATHY; FIBER DEGENERATION; HYPOXIC NEUROPATHY; SURAL NERVE; RELEVANCE;
Keywords:
ISCHEMIC NEUROPATHY; VASO-NERVORUM; LUMINAL OCCLUSION; VASCULAR WALL CELL PROLIFERATION; LOWER LIMB NERVE; AXONAL ATROPHY; SODIUM LAURATE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
H. Yasuda et al., "AN ANIMAL-MODEL OF CHRONIC ISCHEMIC NEUROPATHY WITH PROLIFERATIVE CHANGES OF NERVE MICROVESSEL WALL", Journal of the neurological sciences, 120(1), 1993, pp. 64-70

Abstract

In order to produce a model of ischemic neuropathy with neural microvascular alterations, sodium laurate was injected into a femoral arteryand saline into the contralateral artery at the mid-thigh level in Sprague-Dawley rats aged 11 weeks. In view of the dose-related findings,0.3 mg sodium laurate dissolved in 0.1 ml saline was used for the main experiment. The laurate-injected leg showed paresis during the experimental period. On day 1-7, various stages of Wallerian degeneration and acute microvascular changes were found. At 1 month, regenerating myelinated nerve fibers (MNFs) were found at the central or total fascicular area mainly in the distal tibial nerve. Morphometric analyses suggested that MNFs other than regenerating fibers are atrophic ones. Theproliferative changes of nutrient microvascular walls were striking. The percent of closed epineurial microvessels was significantly largeron the laurate-injected sides and inversely associated with the diameter of MNFs. At 7 months, the attenuation of MNFs was more prominent and microvascular alterations were persistently observed. These pathological findings resemble those of chronic ischemic neuropathy including. diabetic neuropathy, suggesting that this neuropathy model might provide some valuable and useful clues for clarifying the pathogenesis ofchronic ischemic neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 14:51:48