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Titolo:
INSPIRATORY PROLONGATION BY VAGAL AFFERENTS FROM PULMONARY MECHANORECEPTORS IN RABBITS
Autore:
SIBUYA M; KANAMARU A; HOMMA I;
Indirizzi:
SHOWA UNIV,SCH MED,DEPT PHYSIOL,SHINAGAWA KU TOKYO 142 JAPAN
Titolo Testata:
Japanese Journal of Physiology
fascicolo: 5, volume: 43, anno: 1993,
pagine: 669 - 684
SICI:
0021-521X(1993)43:5<669:IPBVAF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL-SIGNIFICANCE; C-FIBERS; RECEPTORS; STIMULATION; IRRITANT; LUNGS; DOGS; CAT;
Keywords:
RESPIRATORY REFLEX; VAGUS NERVE COOLING; APNEUSIS; INSPIRATORY OFF-SWITCH; PULMONARY C-FIBERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Sibuya et al., "INSPIRATORY PROLONGATION BY VAGAL AFFERENTS FROM PULMONARY MECHANORECEPTORS IN RABBITS", Japanese Journal of Physiology, 43(5), 1993, pp. 669-684

Abstract

Graded inflation and deflation pressures were transiently applied to the airway, and the effects on the inspiratory (T(I)) and expiratory (T(E)) durations were studied in twelve Japanese white rabbits tracheotomized and anesthetized with urethane and chloralose. Without vagal cooling, lung inflation prolonged T(E), whereas changes in T(I) were small and in consistent. The bilateral vagus nerves were cooled to 7-degrees-C to block myelinated fibers, and to study the effects of C-fiber afferents. During vagal cooling to 7-degrees-C, inflation dose dependently prolonged the first T(I) with no consistent change in T(E). Without vagal cooling, lung deflation shortened T(E) of the first and succeeding breaths, and prolonged T(I) of the first breath to manifest apneusis. Deflation applied at the vagal temperature of 7-degrees-C induced slight shortening of T(I) and T(E) in 6 of the 12 rabbits. All thesechanges were blocked when the vagus nerves were cooled to 1-degrees-C. The results may indicate that vagal afferents from irritant receptors shorten T(E), and C-fiber afferents prolong T(I). High irritant afferent activity may markedly shorten T(E), causing tidal inspiratory activities to merge and manifest apneusis. Capsaicin, which is suggested to be a ''selective'' stimulant of C-fiber receptors was injected intothe right atrium in 4 of the 12 rabbits. The chief changes were T(E) shortening without vagal cooling, and T(I) prolongation during coolingto 7-degrees-C. This suggests that capsaicin injected into the pulmonary circulation stimulates both the irritant and C-fiber receptors andthe C-fiber afferents may prolong T(I) even when stimulated chemically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:42:26