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Titolo:
PRIMARY LEIOMYOSARCOMAS OF THE LUNG - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 18 CASES
Autore:
MORAN CA; SUSTER S; ABBONDANZO SL; KOSS MN;
Indirizzi:
ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,ROOM 3017 WASHINGTON DC 20306 ARMED FORCES INST PATHOL,DEPT HEMATOL & LYMPHAT PATHOL WASHINGTON DC 20306 MT SINAI MED CTR,ARKADI M RYWLIN DEPT PATHOL & LAB MED MIAMI FL 00000 UNIV MIAMI,SCH MED MIAMI FL 00000
Titolo Testata:
Modern pathology
fascicolo: 2, volume: 10, anno: 1997,
pagine: 121 - 128
SICI:
0893-3952(1997)10:2<121:PLOTL->2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE TUMORS; BRONCHOPULMONARY LEIOMYOSARCOMA; SARCOMAS; NEOPLASMS; TRACT;
Keywords:
ENDOBRONCHIAL LESIONS; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; LUNG TUMORS; PULMONARY SARCOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Moran et al., "PRIMARY LEIOMYOSARCOMAS OF THE LUNG - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 18 CASES", Modern pathology, 10(2), 1997, pp. 121-128

Abstract

We studied 18 patients with primary malignant smooth muscle tumors ofthe lung (7 women and 11 men, 5-76 yr old, with a mean age of 50 yr). Lesions varied from 1.7 to 10 cm in greatest diameter. The tumors were classified as low (4 cases), intermediate (2), or high grade (12). Low-grade lesions were characterized by an orderly proliferation of fascicles of spindle cells that intersected at right angles and showed oval-to-spindle cells with cigar-shaped nuclei, minimal pleomorphism, and low mitotic activity, without hemorrhage or necrosis. Intermediate-grade lesions retained the fascicular configuration but showed increased cellularity with atypia and dense chromatin pattern, occasional pleomorphism, and mild increase in mitotic activity. High-grade lesions showed high cellularity, marked pleomorphism and atypia, frequent areas of hemorrhage and necrosis, and high mitotic activity. Immunohistochemical studies in 16 cases showed positive staining of tumor cells with smooth muscle actin in 12, desmin in 5, and coexpression of actin and/or desmin and keratin in 3. Six patients with low- and intermediate-grade lesions were alive and well from 2 to 12 years after diagnosis (mean follow-up time, 6 yr); 8 with high-grade lesions died of their tumors with widespread metastases from 1 to 24 months after diagnosis (median survival time, 5 mo). One patient whose tumor showed features of high-grade leiomyosarcoma was alive and well 12 years after surgery. Three patients with high-grade tumors were lost to follow-up. Our findings suggest that histologic grade may be the most reliable prognostic parameter for predicting clinical behavior in primary leiomyosarcoma ofthe lung and that smooth muscle actin is the most sensitive immunohistochemical marker for establishing the diagnosis in these tumors. Primary leiomyosarcoma should be considered in the differential diagnosis of pulmonary spindle cell neoplasms; histologic grading may be of value in the planning of therapy and assessment of prognosis for these lesions.

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Documento generato il 14/07/20 alle ore 12:02:22