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Titolo:
VANCOMYCIN RESISTANCE IN GRAM-POSITIVE ORGANISMS
Autore:
ARDUINO RC; MURRAY BE;
Indirizzi:
UNIV TEXAS,HSC,CTR INFECT DIS,6431 FANNIN,ROOM 1728 JFB HOUSTON TX 77030 UNIV TEXAS,SCH MED,DEPT INTERNAL MED HOUSTON TX 77030
Titolo Testata:
Current opinion in infectious diseases
fascicolo: 6, volume: 6, anno: 1993,
pagine: 715 - 724
SICI:
0951-7375(1993)6:6<715:VRIGO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Arduino e B.E. Murray, "VANCOMYCIN RESISTANCE IN GRAM-POSITIVE ORGANISMS", Current opinion in infectious diseases, 6(6), 1993, pp. 715-724

Abstract

Vancomycin is active against most Gram-positive bacteria. The genera Leuconostoc, Lactobacillus, Pediococcus and Erysipelothrix are normally resistant to vancomycin but do not represent a major problem becausethe incidence of infections caused by these organisms is low and theyare usually susceptible to other antimicrobial agents. More disturbing, however, is the emergence of vancomycin resistance in clinical enterococcal and staphylococcal isolates. Acquisition of new genes is responsible for vancomycin resistance in isolates or Enterococcus faecalisand Enterococcus faecium. Whereas low-level vancomycin resistance appears to be a normal or inherent characteristic of Enterococcus gallinarum and Enterococcus casseliflavus. To date, vancomycin resistance hasnot been reported in clinical isolates of Streptococcus spp. or Staphylococcus aureus. However, stepwise decreases in vancomycin susceptibility have been observed in coagulase-negative staphylococci, particularly Staphylococcus haemolyticus. Because coagulase-negative staphylococci and enterococci are now the second and third most common organismscausing hospital-acquired bloodstream infection in the USA, respectively, and because resistance to vancomycin in these organisms is usually accompanied by multiple resistance to antimicrobial agents, vancomycin-resistant enterococci and staphylococci represent a major problem for the physician. Efforts to avoid their emergence by appropriate antibiotic use and to stop their dissemination by adherence to infection control practices are needed as few therapeutic alternatives are currently available.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 06:56:08