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Titolo:
SYNTHESIS OF PURINE-ACRIDINE HYBRID MOLECULES RELATED TO ARTIFICIAL ENDONUCLEASES
Autore:
FKYERAT A; DEMEUNYNCK M; CONSTANT JF; LHOMME J;
Indirizzi:
UNIV J FOURIER,LEDSS,CNRS,URA 332,BP 53 F-38041 GRENOBLE 9 FRANCE UNIV J FOURIER,LEDSS,CNRS,URA 332 F-38041 GRENOBLE 9 FRANCE
Titolo Testata:
Tetrahedron
fascicolo: 48, volume: 49, anno: 1993,
pagine: 11237 - 11252
SICI:
0040-4020(1993)49:48<11237:SOPHMR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
APURINIC SITES; POLYAMINE ANALOGS; ESCHERICHIA-COLI; BETA-ELIMINATION; ABASIC SITES; DNA; SPERMIDINE; NICKING; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Fkyerat et al., "SYNTHESIS OF PURINE-ACRIDINE HYBRID MOLECULES RELATED TO ARTIFICIAL ENDONUCLEASES", Tetrahedron, 49(48), 1993, pp. 11237-11252

Abstract

In the course of a program devoted to the synthesis of artificial endonucleases, we have previously reported a series of hybrid molecules in which a purine is linked to an intercalating drug by a polyamino chain. These molecules recognize and cleave selectively abasic sites in DNA with very high efficiency. In order to get insight into the mechanism of recognition and cleavage, we have prepared a new series of molecules in which the purine is linked to an amino-acridine by an aliphatic chain containing amido or/and amino groups. The key intermediates are alpha-halo-omega-amino polyaza chains which may be of general use aslinkers in bioconjugate chemistry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:06:20