Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RELAXOMETRY, ANIMAL BIODISTRIBUTION, AND MAGNETIC-RESONANCE-IMAGING STUDIES OF SOME NEW GADOLINIUM-(III) MACROCYCLIC PHOSPHINATE AND PHOSPHONATE MONOESTER COMPLEXES
Autore:
GERALDES CFGC; SHERRY AD; LAZAR I; MISETA A; BOGNER P; BERENYI E; SUMEGI B; KIEFER GE; MCMILLAN K; MATON F; MULLER RN;
Indirizzi:
UNIV TEXAS,SW MED CTR,CTR MAGNET RESONANCE,5801 FOREST PK RD DALLAS TX 75235 UNIV COIMBRA,DEPT BIOCHEM P-3000 COIMBRA PORTUGAL UNIV COIMBRA,CTR NEUROSCI P-3000 COIMBRA PORTUGAL UNIV TEXAS,DEPT CHEM RICHARDSON TX 75083 UNIV TEXAS,SW MED CTR DALLAS,MARY NELL & RALPH B ROGERS MAGNET RESONANCE CTR DALLAS TX 00000 UNIV MONS HAINAUT,FAC MED,DEPT ORGAN CHEM B-7000 MONS BELGIUM UNIV MONS HAINAUT,FAC MED,NUCL MAGNET RESONANCE LAB B-7000 MONS BELGIUM UNIV PECS,SCH MED,INST BIOCHEM H-7624 PECS HUNGARY DOW CHEM CO USA,DESIGN CHEM RES & DEV FREEPORT TX 00000 UNIV PECS,SCH MED,DEPT CLIN CHEM H-7643 PECS HUNGARY PANNON UNIV AGR,CTR DIAGNOST H-7401 KAPOSVAR HUNGARY
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 6, volume: 30, anno: 1993,
pagine: 696 - 703
SICI:
0740-3194(1993)30:6<696:RABAMS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGENT; SPECTROSCOPY; CHELATE; INVIVO; SHIFTS; GD-3+; BRAIN; DOTA; MRI;
Keywords:
GADOLINIUM; CONTRAST AGENTS; MACROCYCLIC CHELATES; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C.F.G.C. Geraldes et al., "RELAXOMETRY, ANIMAL BIODISTRIBUTION, AND MAGNETIC-RESONANCE-IMAGING STUDIES OF SOME NEW GADOLINIUM-(III) MACROCYCLIC PHOSPHINATE AND PHOSPHONATE MONOESTER COMPLEXES", Magnetic resonance in medicine, 30(6), 1993, pp. 696-703

Abstract

The Gd3+ complexes of three new phosphorus containing tetraaza macrocycles (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene ethylphosphonic acid), H4DOTEP; 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid monoethylester), H4DOTPME; and the corresponding n-butyl ester, H4DOTPMB) were prepared and examined for possible use as MRI contrast agents. Although thermodynamically and kinetically less stable than Gd(DOTA)- in saline and HSA solution, the stability of these new macrocyclic complexes appears to be sufficientlyhigh for In vivo applications. NMRD relaxivity profiles of the three complexes indicate that the number of inner sphere water molecules forthese chelates is less-than-or-equal-to 1 and that the more hydrophobic chelate, Gd(DOTPMB), binds to human serum albumin (HSA). Biodistribution studies of the radioactive Sm-153 or Gd-159 chelates in rats, gamma imaging of the Sm-153 chelates in rats, and proton MRI studies of the nonradioactive. Gd3+ chelates in rabbits all indicate that the DOTPMB complexes accumulate preferentially in the liver, spleen, and small intestines while the more hydrophilic DOTEP and DOTPME complexes appear to display renal clearances similar to other low molecular weight contrast agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:18:17