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Titolo:
CURRENT PERSPECTIVES ON ANTIRETROVIRAL THERAPY
Autore:
FLETCHER CV;
Indirizzi:
UNIV MINNESOTA,COLL PHARM,DEPT PHARM PRACTICE,7-115 HSUF,308 HARVARD ST SE MINNEAPOLIS MN 55455
Titolo Testata:
Pharmacotherapy
fascicolo: 6, volume: 13, anno: 1993,
pagine: 627 - 633
SICI:
0277-0008(1993)13:6<627:CPOAT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS-INFECTION; AIDS-RELATED COMPLEX; RECOMBINANT SOLUBLE CD4; REVERSE-TRANSCRIPTASE INHIBITION; PLACEBO-CONTROLLED TRIAL; PHASE-I; ZIDOVUDINE AZT; CYTOMEGALOVIRUS RETINITIS; FOSCARNET THERAPY; HIV-1 PROTEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
C.V. Fletcher, "CURRENT PERSPECTIVES ON ANTIRETROVIRAL THERAPY", Pharmacotherapy, 13(6), 1993, pp. 627-633

Abstract

Current estimates suggest that at least 1 million persons in the United States are infected with the human immunodeficiency virus (HIV), the cause of the acquired immunodeficiency syndrome. Knowledge of the life cycle of HIV has provided the fundamental information necessary to initiate programs that will identify drugs to treat the infection. Inhibition of reverse transcriptase represents the only strategy of proved clinical value. Three such drugs are available: zidovudine, didanosine, and zalcitabine. Zidovudine is the only proved agent for therapy of asymptomatic HIV infection; and for symptomatic disease, monotherapywith zidovudine must also be regarded as the first-line approach. Forpatients who are intolerant, are failing clinically, or have receivedprior long-term treatment with zidovudine, monotherapy with didanosine or zalcitabine, or a combination of zidovudine and zalcitabine are alternatives. Progress is being made in the treatment of HIV infection,but the considerable challenge to affect the inexorable progressive nature of HIV disease remains daunting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:28:16