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Titolo:
IMPAIRED STARTLE PREPULSE INHIBITION AND HABITUATION IN PATIENTS WITHSCHIZOTYPAL PERSONALITY-DISORDER
Autore:
CADENHEAD KS; GEYER MA; BRAFF DL;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,0603,9500 GILMAN DR LA JOLLA CA 92093
Titolo Testata:
The American journal of psychiatry
fascicolo: 12, volume: 150, anno: 1993,
pagine: 1862 - 1867
SICI:
0002-953X(1993)150:12<1862:ISPIAH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; PHYSICAL ANHEDONIA; REFLEX; DEFICITS; MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Cadenhead et al., "IMPAIRED STARTLE PREPULSE INHIBITION AND HABITUATION IN PATIENTS WITHSCHIZOTYPAL PERSONALITY-DISORDER", The American journal of psychiatry, 150(12), 1993, pp. 1862-1867

Abstract

Objective: Information processing measures that serve as biological markers for schizophrenia can help to define the boundaries of schizophrenia. Prepulse inhibition and habituation of the blink reflex component of startle, which are thought to reflect an individual's ability toscreen out or ''gate'' irrelevant sensory stimuli, are impaired in patients with schizophrenia. These deficits in sensorimotor gating and habituation in schizophrenic patients may lead to sensory overload and,secondarily, cognitive fragmentation, disorganization, and thought disorder. The goal of this study was to test two hypotheses: 1) patientswith schizotypal personality disorder would show a loss of sensorimotor gating reflected by impaired prepulse inhibition of the human startle response and 2) patients with schizotypal personality disorder would show deficits in startle habituation consistent with the deficits seen in patients with schizophrenia. Method: Prepulse inhibition and habituation were assessed in 12 men and four women who met DSM-III-R criteria for schizotypal personality disorder and in 22 normal comparison subjects. Results: Patients with schizotypal personality disorder had deficits in acoustic prepulse inhibition and habituation similar to the deficits observed in patients with schizophrenia. Although there were no differences between patients with schizotypal personality disorder and normal subjects in latency from acoustic startle stimuli to response, latency facilitation was produced by the prepulse in both groups. Conclusions: This pattern of changes in amplitude and latency of thestartle response suggests that subjects with schizotypal personality disorder perceive the prepulse stimuli but still demonstrate deficientsensorimotor gating of amplitude. These findings support the importance of startle prepulse inhibition and startle habituation as biological markers for schizophrenia spectrum disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:06:22