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Titolo:
ACTIVATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT BY SKIN-SENSITIZING CHEMICALS IN TRANSGENIC MICE
Autore:
MORREY JD; JACKSON MK; BUNCH TD; SIDWELL RW;
Indirizzi:
UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,INST ANTIVIRAL RES,VSB 204 LOGAN UT 84322
Titolo Testata:
Intervirology
fascicolo: 2, volume: 36, anno: 1993,
pagine: 65 - 71
SICI:
0300-5526(1993)36:2<65:AOTHTL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LANGERHANS CELLS; IRRADIATION; INFECTION;
Keywords:
DENDRITIC CELLS; DINITROCHLOROBENZENE; HUMAN IMMUNODEFICIENCY VIRUS; LONG-TERMINAL REPEAT; TRANSGENIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Morrey et al., "ACTIVATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT BY SKIN-SENSITIZING CHEMICALS IN TRANSGENIC MICE", Intervirology, 36(2), 1993, pp. 65-71

Abstract

Topical dinitrochlorobenzene (DNCB) is often used for evaluating contact skin hypersensitivity in immunocompromised patients. We have determined, in this study, that topical application of DNCB alone, even without induction of contact skin hypersensitivity, was sufficient to observe activation of the human immunodeficiency virus promoter (long terminal repeat) in the skin of an HIV-1 long terminal repeat-luciferase transgenic mouse model. Such treatment might be contraindicative in patients infected with the human immunodeficiency virus, because in earlier studies DNCB-exposed skin dendritic cells might migrate into draining lymph nodes which play an important role in AIDS pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 06:59:02