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Titolo:
ROLE OF THE MEDIAL SEPTAL AREA ON THE CARDIOVASCULAR, FLUID AND ELECTROLYTIC RESPONSES TO ANGIOTENSIN-II AND CHOLINERGIC ACTIVATION INTO THE SUBFORNICAL ORGAN IN RATS
Autore:
COLOMBARI DSD; HAIBARA AS; CAMARGO LAD; SAAD WA; RENZI A; DELUCA LA; MENANI JV;
Indirizzi:
PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,POB 331,1680 HUMAITA ST BR-14801 ARARAQUARA SP BRAZIL PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,POB 331,1680 HUMAITA ST BR-14801 ARARAQUARA SP BRAZIL
Titolo Testata:
Brain research bulletin
fascicolo: 3, volume: 33, anno: 1994,
pagine: 249 - 254
SICI:
0361-9230(1994)33:3<249:ROTMSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
WATER-INTAKE; NATRIURETIC RESPONSES; STIMULATION; DRINKING; PRESSOR; VASOPRESSIN; CONNECTIONS; SUPPRESSES; NEURONS; LESION;
Keywords:
SUBFORNICAL ORGAN; SEPTAL AREA; WATER INTAKE; NATRIURESIS; ARTERIAL PRESSURE; ANGIOTENSIN-II;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.S.D. Colombari et al., "ROLE OF THE MEDIAL SEPTAL AREA ON THE CARDIOVASCULAR, FLUID AND ELECTROLYTIC RESPONSES TO ANGIOTENSIN-II AND CHOLINERGIC ACTIVATION INTO THE SUBFORNICAL ORGAN IN RATS", Brain research bulletin, 33(3), 1994, pp. 249-254

Abstract

In the present study we investigate the effect of electrolytic lesionof the medial septal area (MSA) on the pressor and dipsogenic response to cholinergic activation and angiotensin II (ANGII) injection into the subfornical organ (SFO) in rats. In addition the effect of MSA lesion on the natriuresis, kaliuresis and diuresis after cholinergic activation of the SFO was also investigated. Sham- and MSA-lesioned rats with a stainless steel cannula implanted into the SFO was used. The injection of ANGII (12 ng) into the SFO in sham rats produced pressor (24+/- 2 mmHg) and dipsogenic (9.6 +/- 1.1 ml/h) responses. MSA lesion, both acute (2-6 days) and chronic (15-19 days), reduced the pressor (14 +/- 2 mmHg) and dipsogenic (2.7 +/- 1 ml/h) responses to ANGII into SFO. The injection of the cholinergic agonist carbachol (2 nmol) into the SFO in sham rats produced pressor (48 +/- 4 mmHg), dipsogenic (10 /- 1.2 ml/h), natriuretic (457 +/- 58 muEq/2 h) and kaliuretic (249 +/- 16 muEq/2 h) responses. Acute, but not chronic MSA lesion reduced the pressor (27 +/- 3 mmHg), natriuretic (198 +/- 55 muEq/2 h) and kaliuretic (128 +/- 16 muEq/2 h) responses to carbachol into SFO. No change in the dipsogenic response to carbachol into the SFO was observed inMSA-lesioned rats. Antidiuresis after carbachol was observed only in MSA-lesioned rats. The present results show that the MSA plays a role on the pressor, natriuretic and kaliuretic responses to cholinergic activation of the SFO in rats and on the pressor and dipsogenic responses to ANGII into the same area. In addition, they provide circumstancial evidence for separate circuits subserving the dipsogenic response tocentral cholinergic and angiotensinergic activation. A facilited diuresis after MSA lesion is also suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:27:55