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Titolo:
LOCALIZATION OF IBF AS A D-2 DOPAMINE-RECEPTOR IMAGING AGENT IN NONHUMAN-PRIMATES
Autore:
BILLINGS JJ; GUO YZ; KUNG MP; KUNG HF;
Indirizzi:
UNIV PENN,DEPT RADIOL,3700 MARKET ST PHILADELPHIA PA 19104 UNIV PENN,DEPT RADIOL,3700 MARKET ST PHILADELPHIA PA 19104
Titolo Testata:
European journal of nuclear medicine
fascicolo: 12, volume: 20, anno: 1993,
pagine: 1146 - 1153
SICI:
0340-6997(1993)20:12<1146:LOIAAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY; RAT-BRAIN; PHARMACOLOGICAL CHARACTERIZATION; INITIAL EXPERIENCE; WILSONS-DISEASE; INVIVO BINDING; I-123; BIODISTRIBUTION; RADIOLIGANDS;
Keywords:
SINGLE-PHOTON EMISSION TOMOGRAPHY; D-2 DOPAMINE RECEPTOR; BRAIN IMAGING; BASAL GANGLIA; EYE UPTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Billings et al., "LOCALIZATION OF IBF AS A D-2 DOPAMINE-RECEPTOR IMAGING AGENT IN NONHUMAN-PRIMATES", European journal of nuclear medicine, 20(12), 1993, pp. 1146-1153

Abstract

Preliminary study of iodine-123 labeled IBF, (S)-5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl] carboxamido-2, 3-dihydrobenzofuran, has demonstrated the potential of using this agent to evaluate the status of theCNS D-2 dopamine receptor in humans. To further characterize this ligand and evaluate single-photon emission tomography (SPET) quantitation, a detailed biodistribution study in monkeys (Macaca fascicularis) with I-123- and I-125-IBF was performed. The dual tracer was simultaneously injected for in vivo imaging, biodistribution, and ex vivo autoradiography in the same monkey. After the injection, SPET data (10 min/frame x 15) were collected with a triple-head gamma camera. Dynamic imaging data indicated that IBF localized in basal ganglia (BG) with a half life of 90-120 min. Other regions, i.e., cerebellum (CB) and cortex (CX), showed very low uptake. At 2.2 h after the injection, the monkeywas sacrificed. Organ distribution data indicated that, as expected, there was a significant uptake in basal ganglia (0.029% ID/g), and theBG/CB and BG/CX ratios were 17.8 and 14.2 respectively. Lower ratios were obtained from SPET image analysis (BG/CB=3.5 at 2.5h). The eye uptake was observed with SPET, but was only quantified on autoradiogramswith significant uptake (0.017% ID/g). Autoradiography of the eye demonstrated that predominant uptake was localized in the ciliary body and the choroid. The selective retention and high BG/CB ratio of I-123-IBF make it a useful agent for in vivo D-2 dopamine receptor imaging with SPET.

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Documento generato il 09/04/20 alle ore 18:30:52