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Titolo:
SYSTEMIC CELL-MEDIATED IMMUNE REACTIVITY IN WOMEN WITH RECURRENT VULVO-VAGINAL CANDIDIASIS
Autore:
FIDEL PL; LYNCH ME; REDONDOLOPEZ V; SOBEL JD; ROBINSON R;
Indirizzi:
HARPER GRACE HOSP,DIV INFECT DIS,2N PROFESSIONAL BLDG,SUITE 202,4160 JOHN R DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DIV INFECT DIS DETROIT MI 48201
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 168, anno: 1993,
pagine: 1458 - 1465
SICI:
0022-1899(1993)168:6<1458:SCIRIW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MUCOCUTANEOUS CANDIDIASIS; INDUCED LYMPHOCYTE-PROLIFERATION; CANDIDAL VAGINITIS; PLASMA INHIBITOR; ALBICANS; INVITRO; SERUM; INFECTION; REVERSAL; MANNAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Fidel et al., "SYSTEMIC CELL-MEDIATED IMMUNE REACTIVITY IN WOMEN WITH RECURRENT VULVO-VAGINAL CANDIDIASIS", The Journal of infectious diseases, 168(6), 1993, pp. 1458-1465

Abstract

It has been suggested that impaired cell-mediated immunity (CMI) against Candida antigens is responsible for susceptibility to recurrent vulvovaginal candidiasis (RVVC) in adult women. To address this, we conducted a comprehensive longitudinal study examining in vivo and in vitro systemic CMI reactivity in RVVC patients. Results showed that RVVC patients frequently demonstrated a transient loss of Candida-specific delayed cutaneous skin test reactivity during episodes of symptomatic vaginitis. In contrast, in vitro peripheral blood lymphoproliferation and Th 1-type lymphokine production by RVVC patients in response to a Tcell mitogen and multiple Candida and bacterial antigens were similarto controls both during acute episodes of vaginitis and during periods of infection-free remission. These results suggest that women with RVVC have no detectable impairment of systemic CMI in peripheral blood and that transient reductions in skin test reactivity appear to be a result of vaginal Candida infection and not a predisposing factor to RVVC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 00:37:04