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Titolo:
QUINOLINIC ACID IN THE CEREBROSPINAL-FLUID OF CHILDREN WITH SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DISEASE - RELATIONSHIPS TO CLINICAL STATUS AND THERAPEUTIC RESPONSE
Autore:
BROUWERS P; HEYES MP; MOSS HA; WOLTERS PL; POPLACK DG; MARKEY SP; PIZZO PA;
Indirizzi:
NCI,CTR CLIN,PEDIAT BRANCH,ROOM 13N240 BETHESDA MD 20892 NCI,CTR MED ILLNESS COUNSELING,PEDIAT BRANCH BETHESDA MD 20892 NIMH,CLIN SCI LAB,ANALYT BIOCHEM SECT BETHESDA MD 20892
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 168, anno: 1993,
pagine: 1380 - 1386
SICI:
0022-1899(1993)168:6<1380:QAITCO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; HIV-1 INFECTION; PROGRESSIVE ENCEPHALOPATHY; NEUROACTIVE KYNURENINES; CONTINUOUS-INFUSION; INTERFERON-GAMMA; L-TRYPTOPHAN; FACTOR-ALPHA; RAT-BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
P. Brouwers et al., "QUINOLINIC ACID IN THE CEREBROSPINAL-FLUID OF CHILDREN WITH SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DISEASE - RELATIONSHIPS TO CLINICAL STATUS AND THERAPEUTIC RESPONSE", The Journal of infectious diseases, 168(6), 1993, pp. 1380-1386

Abstract

Quinolinic acid (QUIN) is a neurotoxin implicated in the neurologic deficits associated with human immunodeficiency virus type 1 (HIV-1) infection. Forty children with symptomatic HIV-1 disease had elevated (P< .001) cerebrospinal fluid (CSF) QUIN levels (55.8 +/- 8.9 nM) compared with controls (14.9 +/- 3.0 nM). Age-adjusted CSF QUIN concentrations in HIV-1-infected children were predicted by the general index of mental abilities (GIMA, from an age-appropriate intelligence test; r =-0.45, P < .01). Zidovudine therapy reduced CSF QUIN from 64.1 +/- 16.3 to 19.7 +/- 5.2 nM (P < .01; N = 16) and increased GIMA from 76.8 +/- 5.2 to 87.2 +/- 6.3 (P < .001). Encephalopathic HIV-1-infected patients had higher CSF QUIN levels than patients without encephalopathy (79.6 +/- 16.1 vs. 32.7 +/- 6.7 nM, P < .01). CSF QUIN concentrations were also higher (P < .001) in patients who died less-than-or-equal-to 3 years after their baseline assessment, compared with those who were still alive. These results warrant further investigation of CSF QUIN in HIV-infected children as a mediator of neurologic dysfunction and a supplemental marker of neurologic disease, particularly when combined with measures of neurocognitive functioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:12:56