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Titolo:
EFFECTS OF SUMATRIPTAN ON THE CEREBRAL INTRAPARENCHYMAL MICROCIRCULATION IN THE CAT
Autore:
KOBARI M; FUKUUCHI Y; TOMITA M; TANAHASHI N; KONNO S; TAKEDA H;
Indirizzi:
KEIO UNIV,SCH MED,DEPT NEUROL,35 SHINANOMACHI,SHINJUKU KU TOKYO 108 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 110, anno: 1993,
pagine: 1445 - 1448
SICI:
0007-1188(1993)110:4<1445:EOSOTC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMIGRAINE DRUG SUMATRIPTAN; BLOOD-FLOW VELOCITY; ACUTE MIGRAINE; 5-HT1-LIKE RECEPTORS; 5-HT RECEPTORS; BASILAR ARTERY; GR43175; VASOCONSTRICTOR; CONTRACTION; AGONIST;
Keywords:
CEREBRAL BLOOD FLOW; CEREBRAL VESSEL; 5-HYDROXYTRYPTAMINE RECEPTOR; MIGRAINE; PHOTOELECTRIC METHOD; SUMATRIPTAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Kobari et al., "EFFECTS OF SUMATRIPTAN ON THE CEREBRAL INTRAPARENCHYMAL MICROCIRCULATION IN THE CAT", British Journal of Pharmacology, 110(4), 1993, pp. 1445-1448

Abstract

1 Sumatriptan, a 5-hydroxytryptamine (5-HT)1-like receptor agonist, is effective against the headache of migraine. The effects of sumatriptan injected via the carotid artery on the cerebral microcirculation were studied in 10 anaesthetized cats. 2 The local cerebral blood volume(CBV), mean transit time of blood (MTT) and cerebral blood flow (CBF)in the parieto-temporal cortex were measured by a photoelectric method. CBV represents the cumulative dimensions of the cerebral microvessels. 3 Sumatriptan at 5 and 50 mug kg-1 had no significant effects on the CBV, MTT, CBF, and mean arterial blood pressure (MABP); 500 mug kg-1 of sumatriptan reduced the CBV, prolonged the MTT, and decreased theCBF (approximately - 20%) without affecting the MABP. Sumatriptan, 5 mg kg-1, elicited transient reductions in CBV and CBF, which were attributable to the rapid and marked falls of MABP seen with this dose. 4 Thus, while a high dose of sumatriptan (500 mug kg-1) exhibits direct vasoconstrictor actions on the cerebral vessels, low doses of sumatriptan, within the therapeutic range, elicit no vasoconstriction. The data do not support a vasoconstrictor action of sumatriptan playing a primary role in reversing the headache of migraine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:00:11