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Titolo:
5-HT(3) ANTAGONISTS REDUCE MORPHINE SELF-ADMINISTRATION IN RATS
Autore:
HUI SCG; SEVILLA EL; OGLE CW;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHARMACOL HONG KONG HONG KONG CEBU INST MED,DEPT PHARMACOL CEBU CITY PHILIPPINES
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 110, anno: 1993,
pagine: 1341 - 1346
SICI:
0007-1188(1993)110:4<1341:5ARMSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; RECEPTOR ANTAGONISTS; MESOLIMBIC SYSTEM; HEROIN REWARD; DOPAMINE; GR38032F; LESIONS; COCAINE; BRAIN; DRUGS;
Keywords:
MORPHINE INTAKE; ONDANSETRON; TROPISETRON; CYPROHEPTADINE; RATS; SELF ADMINISTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.C.G. Hui et al., "5-HT(3) ANTAGONISTS REDUCE MORPHINE SELF-ADMINISTRATION IN RATS", British Journal of Pharmacology, 110(4), 1993, pp. 1341-1346

Abstract

1 The effects of the 5-HT3 receptor antagonists, ondansetron and tropisetron, on morphine consumption were studied in naive and morphine-dependent rats. 2 The administration of ondansetron (1 mug kg-1, i.p. twice daily) 7 days prior to, and during a 21-day period of, morphine availability (increasing concentration from 0.1 to 0.4 mg ml-1) in 5% sucrose solution reduced opiate intake from the 9th day of morphine treatment. 3 The administration of ondansetron (0.1 mug kg-1, i.p. twice daily) or tropisetron (0.1 mug kg-1, i.p. twice daily) on the 14th day of the 21-day period of morphine treatment failed to reduce opiate consumption. Administration of the larger doses of tropisetron (I mug kg-1) or ondansetron (1 mug kg-1) reduced morphine consumption. 4 After receiving 21 days of treatment with morphine alone or with the ondansetron or tropisetron regimens identified above, the sucrose solutions were substituted with tap water for 7 days. These detoxified rats were then allowed a free choice of sucrose or morphine for 10 days. Animals that had received concomitant treatment with ondansetron or tropisetron showed reduced morphine intake when compared with the controls treated with morphine only or with vehicle-treated controls. 5 The administration of cyproheptadine (100 or 250 mug kg-1, i.p. twice daily) on the 14th day of 21-day morphine treatment failed to modify morphine intake and also failed to influence the subsequent intake of the opiate inthe free choice situation. 6 It is concluded that ondansetron and tropisetron can reduce morphine intake in both naive and morphine-dependent rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:30:08