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Titolo:
PHARMACOKINETICS OF PHENOLSULFONPHTHALEIN IN SHEEP
Autore:
DANIELSON TJ; TAYLOR WG;
Indirizzi:
AGR CANADA,RES STN,LIVESTOCK SCI SECT,POB 3000 LETHBRIDGE T1J 4B1 AB CANADA
Titolo Testata:
American journal of veterinary research
fascicolo: 12, volume: 54, anno: 1993,
pagine: 2179 - 2183
SICI:
0002-9645(1993)54:12<2179:POPIS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; PHASE-I; CREATININE; NSC-347512; EXCRETION; SUMMER; WINTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Danielson e W.G. Taylor, "PHARMACOKINETICS OF PHENOLSULFONPHTHALEIN IN SHEEP", American journal of veterinary research, 54(12), 1993, pp. 2179-2183

Abstract

Pharmacokinetic variables of phenolsulfonphthalein (PSP) were determined in sheep after rapid IV injection and IV infusion to steady state. In Suffolk wethers, an average of < 75% of an IV administered dose was eliminated in urine, indicating that measures of systemic clearance overestimate renal clearance in this species. Furthermore, PSP elimination from plasma was more rapid in Suffolk than Rambouillet wethers and, in Suffolk ewes, systemic clearance decreased from mean +/- SD 7.8 /- 0.3 ml/min/kg of body weight to 4.7 +/- 1.1 ml/min/kg at steady-state plasma concentration of 2.4 +/- 0.3 and 151.3 +/- 31.8 mu g/ml, respectively. These observations indicate that, similar to that in otherspecies, systemic clearance of PSP in sheep is concentration-dependent and that significant differences may exist between breeds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:37:30