Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACUTE AND CHRONIC ADMINISTRATION OF BUSPIRONE FAILS TO YIELD ANXIOLYTIC-LIKE EFFECTS IN A MOUSE OPERANT PUNISHMENT PARADIGM
Autore:
MARTIN JR; MOREAU JL; JENCK F; CUMIN R;
Indirizzi:
F HOFFMANN LA ROCHE LTD,PRPN,PRECLIN RES,DIV PHARMA,BLDG 72-150,GRENZACHERSTR 124 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 46, anno: 1993,
pagine: 905 - 910
SICI:
0091-3057(1993)46:4<905:AACAOB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOLOGICAL PROPERTIES; SQUIRREL-MONKEYS; RATS; ANXIETY; DRUGS; DIAZEPAM; BEHAVIOR; EFFICACY; PIGEON; MICE;
Keywords:
ANXIETY; CONFLICT; DRUG-NAIVE AND DRUG-EXPERIENCED MICE; OPERANT PUNISHMENT PARADIGM; BUSPIRONE; DIAZEPAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Martin et al., "ACUTE AND CHRONIC ADMINISTRATION OF BUSPIRONE FAILS TO YIELD ANXIOLYTIC-LIKE EFFECTS IN A MOUSE OPERANT PUNISHMENT PARADIGM", Pharmacology, biochemistry and behavior, 46(4), 1993, pp. 905-910

Abstract

Drug-naive mice failed to exhibit antipunishment effects of ascendingdoses of buspirone (1-30 mg/kg, PO) in an operant punishment paradigm; however, these same mice subsequently exhibited increased punished responding after diazepam (10 mg/kg, PO). In a separate group of drug-naive mice, diazepam (1-30 mg/kg, PO) produced a robust antipunishment effect under identical experimental conditions, but crossover to buspirone (10 mg/kg, PO) failed to enhance punished responding. In a further experiment using this conflict model, two groups of benzodiazepine-experienced mice received daily oral administration of either vehicle or buspirone (5 mg/kg) for four weeks followed by a test with buspirone; neither group exhibited an antipunishment effect. Two other groups of benzodiazepine-experienced mice received either oral vehicle or diazepam (5 mg/kg) daily for four weeks followed by a test with diazepam; both groups exhibited a clear antipunishment effect. Finally, a group of benzodiazepine-experienced mice given vehicle daily for four weeks followed by a test with vehicle failed to exhibit an antipunishment effect. Thus, despite the attempt to optimize some important experimental conditions in this mouse conflict paradigm, buspirone still failed to produce an antipunishment effect. In contrast, diazepam consistentlyexhibited a robust anxiolytic-like effect under the same experimentalconditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:03:10