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Titolo:
THE ROLE OF DOPAMINE AND AMPA KAINATE RECEPTORS IN THE NUCLEUS-ACCUMBENS IN THE HYPERMOTILITY RESPONSE TO MK801
Autore:
WILLINS DL; NARAYANAN S; WALLACE LJ; URETSKY NJ;
Indirizzi:
OHIO STATE UNIV,COLL PHARM,DIV PHARMACOL,500 W 12TH AVE COLUMBUS OH 43210 OHIO STATE UNIV,COLL PHARM,DIV PHARMACOL,500 W 12TH AVE COLUMBUS OH 43210
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 46, anno: 1993,
pagine: 881 - 887
SICI:
0091-3057(1993)46:4<881:TRODAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT ANXIOLYTIC PROPERTIES; INDUCED LOCOMOTOR-ACTIVITY; MONOAMINE-DEPLETED MICE; NMDA ANTAGONIST; ANTICONVULSANT MK-801; POTENT ANTICONVULSANT; 10-IMINE MK-801; ACID RECEPTORS; RAT; SYSTEMS;
Keywords:
NUCLEUS ACCUMBENS; MK801; DOPAMINE; HYPERMOTILITY; AMPA KAINATE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Willins et al., "THE ROLE OF DOPAMINE AND AMPA KAINATE RECEPTORS IN THE NUCLEUS-ACCUMBENS IN THE HYPERMOTILITY RESPONSE TO MK801", Pharmacology, biochemistry and behavior, 46(4), 1993, pp. 881-887

Abstract

The purpose of this study was to evaluate the role of endogenous dopamine in the hypermotility response to MK801. The administration of MK801 (0.1 mg/kg, SC) to rats produced an intense stimulation of coordinated locomotor activity, which was not associated with stereotyped behavior. This stimulatory response was inhibited by pretreatment with either reserpine (5 mg/kg, IP) or alpha-methyl-p-tyrosine (2 doses of 250mg/kg, IP). Similarly, pretreatment with the D2 antagonist eticlopride (0.03 mg/kg, SC) or the D1 antagonist SCH23390 (0.1 mg/kg, SC) produced a marked inhibition of MK801-stimulated hypermotility, and the combination of eticlopride (0.03 mg/kg, SC) and SCH23390 (0.03 mg/kg, SC)produced a greater inhibition of MK801-stimulated locomotion than either agent alone. The administration of SCH23390 or eticlopride directly into the nucleus accumbens inhibited the locomotor response to MK801, with the combination of both drugs producing a greater inhibition than either agent alone. The intra-accumbens administration of the pha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor antagonists DNQX or GAMS also inhibited the locomotor response produced by MK801. These data suggest that the activation of D1 and D2 dopaminergic receptors and AMPA/kainate excitatory amino acid receptors in the nucleus accumbens is required for the stimulation of locomotor activity produced by MK801.

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Documento generato il 26/01/20 alle ore 01:05:10