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Titolo:
MODULATION OF LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR IN INJURED ADULT-RAT SPINAL-CORD MOTONEURONS
Autore:
RENDE M; PROVENZANO C; TONALI P;
Indirizzi:
UNIV PERUGIA,SCH MED,DEPT EXPTL MED & BIOCHEM SCI,ANAT SECT,CP 81 I-06100 PERUGIA ITALY CATHOLIC UNIV SACRED HEART,SCH MED,INST PATHOL I-00168 ROME ITALY CATHOLIC UNIV SACRED HEART,SCH MED,INST NEUROL I-00168 ROME ITALY
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 338, anno: 1993,
pagine: 560 - 574
SICI:
0021-9967(1993)338:4<560:MOLNGR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; NEUROTROPHIC FACTOR; ALPHA-BUNGAROTOXIN; MOTOR NEURONS; NGF-RECEPTOR; CHOLINE-ACETYLTRANSFERASE; ACETYLCHOLINE-RECEPTORS; MESSENGER-RNA; CELL-DEATH; EXPRESSION;
Keywords:
GROWTH FACTORS; SCIATIC NERVE INJURY; AXOTOMY; AXONAL GROWTH; REGENERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
M. Rende et al., "MODULATION OF LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR IN INJURED ADULT-RAT SPINAL-CORD MOTONEURONS", Journal of comparative neurology, 338(4), 1993, pp. 560-574

Abstract

Spinal and brainstem motoneurons of the adult rat reexpress low-affinity nerve growth factor receptor (LNGFR) and its mRNA after axotomy. We have previously reported the time courses of this reexpression aftercut (no regeneration) or crush (followed by regeneration) of the sciatic nerve. We have shown that the length of the different phases of this reexpression (appearance, maintenance and disappearance) can vary according to the type of axotomy. With the present study we expand our previous data and describe and analyze the modulation the LNGFR expression in adult spinal cord motoneurons following different lesion paradigms. In one approach we have imposed three traumatic injuries that still allow regeneration of the sciatic nerve but with a different time course with respect to the crush injury (application of a silicone regeneration chamber, multiple crushes and delayed repair of ligated nerves). In a second approach, we have determined the capability of three toxic or metabolic injuries to induce LNGFR expression without any direct trauma of the nerve (experimental diabetogenesis, botulinum and alpha-bungarotoxin intoxication and 2,5-hexanedione intoxication). In a third approach, we have investigated the effect of the block of the axoplasmic transport on the LNGFR expression following different topicalapplications of vincristine combined with a nerve crush. The results we present are consistent with the idea that: (1) LNGFR immunoreactivity in adult motoneurons is expressed by motoneurons that are attendingto an axonal outgrowth and not a generic signal of cellular damage orimpairment of the motor function; (2) LNGFR expression in these motoneurons is related to and parallels the outgrowth process time frame, and (3) the signal/s that trigger and sustain this reexpression may be retrogradely transported from the periphery. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:52:29