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Titolo:
DEMENTIA IN AIDS PATIENTS - INCIDENCE AND RISK-FACTORS
Autore:
MCARTHUR JC; HOOVER DR; BACELLAR H; MILLER EN; COHEN BA; BECKER JT; GRAHAM NMH; MCARTHUR JH; SELNES OA; JACOBSON LP; VISSCHER BR; CONCHA M; SAAH A; PALENICEK J; ARMENIAN H; FARZADEGAN H; MARGOLICK J; PHAIR JP; CHMIEL JS; BAUER K; VARIAKOJIS D; WESCH J; WOLINSKY SM; DETELS R; CHEN I; DUDLEY J; FAHEY JL; GIORGI JV; MARTINEZMAZA O; NISHANIAN P; TAYLOR J; ZACK J; RINALDO CR; KINGSLEY L; GUPTA P; HO M; MUNOZ A; BEATY T; GALAI N; MEINERT C; NELSON K; PIANTADOSI S; SEMINARA D; SU S; SCHRAGER L; VERMUND SH; KASLOW RA; VANRADEN MJ; OBRAMS I;
Indirizzi:
JOHNS HOPKINS UNIV HOSP,MEYER 6-109,600 N WOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL BALTIMORE MD 21218 UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT LOS ANGELES CA 90024 NORTHWESTERN UNIV,SCH MED,DEPT NEUROL CHICAGO IL 60611 UNIV PITTSBURGH,SCH MED,DEPT PSYCHIAT PITTSBURGH PA 15261 UNIV CALIF LOS ANGELES,SCH PUBL HLTH,DEPT EPIDEMIOL LOS ANGELES CA 90024 NORTHWESTERN UNIV,SCH MED,HOWARD BROWN MEM CLIN CHICAGO IL 60611 UNIV CALIF LOS ANGELES,SCH MED LOS ANGELES CA 90024 UNIV PITTSBURGH,GRAD SCH PUBL HLTH PITTSBURGH PA 15260 NIAID BETHESDA MD 20892 NCI BETHESDA MD 20892
Titolo Testata:
Neurology
fascicolo: 11, volume: 43, anno: 1993,
pagine: 2245 - 2252
SICI:
0028-3878(1993)43:11<2245:DIAP-I>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; TUMOR-NECROSIS-FACTOR; HOMOSEXUAL MEN; VIRUS INFECTION; UNITED-STATES; HIV-INFECTION; SAN-FRANCISCO; FACTOR-ALPHA; COHORT; ZIDOVUDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Mcarthur et al., "DEMENTIA IN AIDS PATIENTS - INCIDENCE AND RISK-FACTORS", Neurology, 43(11), 1993, pp. 2245-2252

Abstract

We determined incidence and future projections of dementia after AIDSonset in 492 homosexual men with AIDS in the Baltimore/Los Angeles sites of the Multicenter AIDS Cohort Study, 64 of whom developed dementia. We studied various risk factors for dementia, including demographicand clinical features, medical history, markers of immune status before AIDS, and zidovudine use. During the first 2 years after AIDS, HIV dementia developed at an annual rate of 7%. Overall, 15% of the cohortfollowed through death developed dementia. The median survival after dementia was 6.0 months. Using a proportional hazards model, risk factors for more rapid development of dementia were lower hemoglobin (relative hazard, 0.59 per additional 2 g/dl; p = 0.0005) and body mass index (relative hazard, 0.64 per additional 5 kg/M2; p = 0.05) 1 to 6 months before AIDS, more constitutional symptoms 7 to 12 months before AIDS (relative hazard, 1.68 per additional symptom, p = 0.005), and older age at AIDS onset (relative hazard, 1.60 per decade older; p = 0.009). In a multivariate model, pre-AIDS hemoglobin remained the most significant predictor of dementia. There were no significant risks definedfrom demographic characteristics, specific AIDS-defining illnesses, zidovudine use before AIDS, or CD4+ lymphocyte count before AIDS. We project that 12 months after the first AIDS diagnosis, 7.1% of survivorswill have dementia. The observed association between anemia, low weight, constitutional symptoms, and dementia suggests a role for cytokines inducing both systemic and neurologic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:41:16