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Titolo:
EFFECTS OF GLUCOSE-LOAD ON BRAIN EXTRACELLULAR LACTATE CONCENTRATION IN CONSCIOUS RATS USING A MICRODIALYSIS TECHNIQUE
Autore:
HARADA M; SAWA T; OKUDA C; MATSUDA T; TANAKA Y;
Indirizzi:
KYOTO PREFECTURAL YOSANOUMI HOSP,DEPT ANESTHESIA KYOTO 62922 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT ANESTHESIOL KYOTO 602 JAPAN
Titolo Testata:
Hormone and Metabolic Research
fascicolo: 11, volume: 25, anno: 1993,
pagine: 560 - 563
SICI:
0018-5043(1993)25:11<560:EOGOBE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL GLUCOSE; HYPOXIA;
Keywords:
HYPERGLYCEMIA; BRAIN GLUCOSE METABOLISM; LACTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M. Harada et al., "EFFECTS OF GLUCOSE-LOAD ON BRAIN EXTRACELLULAR LACTATE CONCENTRATION IN CONSCIOUS RATS USING A MICRODIALYSIS TECHNIQUE", Hormone and Metabolic Research, 25(11), 1993, pp. 560-563

Abstract

Changes in the brain lactate concentration in cerebral extracellular fluid (ECF) during intravenous infusion of glucose and local administration of glucose were investigated in adult, conscious, unrestrained rats, with a microdialysis probe in the posterior hippocampus. The ratswere infused intravenously with either 25 % sucrose solution or 25 % glucose solution at a rate of 16.6 mul . min-1 . 100 g-1 for three hours. The blood glucose concentration reached 17.0+/-2.6 mM at the end of the glucose infusion, and brain ECF glucose showed a parallel changewith the blood glucose concentration and increased to 2.37+/-0.30 mM. However, blood and brain ECF glucose concentrations did not change inanimals infused with the sucrose solution. On the other hand, the blood lactate concentration in the glucose-infused group also increased from 0.93+/-0.18 mM to 2.85+/-0.39 mM at the end of the glucose infusion, which was significantly higher than that measured in the sucrose-infused group. The blood lactate level in the glucose-infused group returned to the basal level by the end of the experiment. Brain ECF lactate concentrations increased from 1.21+/-0.06 mM to 1.69+/-0.11 mM in glucose-infused animals, but did not change in the sucrose-infused animals. The brain ECF lactate concentration showed a positive correlation with the brain ECF glucose concentration in glucose-infused animals. Another group of rats was administered glucose locally for 90 min aftersubstitution of artificial cerebrospinal fluid. As a result, the brain ECF lactate concentration increased significantly from the control level during the glucose loading period, then gradually decreased by the end of the experiment. The present study demonstrated that the brainlactate concentration increased with the brain glucose concentration.

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Documento generato il 18/02/20 alle ore 04:29:48