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Titolo:
LONG-TERM SURVIVAL OF DLA-MATCHED SEGMENTAL SMALL-BOWEL ALLOGRAFTS INDOGS
Autore:
MEIJSSEN MAC; HEINEMAN E; DEBRUIN RWF; WOLVEKAMP MCJ; MARQUET RL; MOLENAAR JC;
Indirizzi:
UNIV LIMBURG HOSP,DEPT SURG,POB 5800 6202 AZ MAASTRICHT NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT INTERNAL MED 2 ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT GEN SURG ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT PEDIAT SURG 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Transplantation
fascicolo: 5, volume: 56, anno: 1993,
pagine: 1062 - 1066
SICI:
0041-1337(1993)56:5<1062:LSODSS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC SMALL-BOWEL; INTESTINAL TRANSPLANTATION; RATS; CYCLOSPORINE; REJECTION; ALLOTRANSPLANTATION; ABSORPTION; GRAFT; NEED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M.A.C. Meijssen et al., "LONG-TERM SURVIVAL OF DLA-MATCHED SEGMENTAL SMALL-BOWEL ALLOGRAFTS INDOGS", Transplantation, 56(5), 1993, pp. 1062-1066

Abstract

The aim of this study was to investigate the combined effect of DLA matching and immunosuppressive therapy on the survival of segmental small-bowel allografts in dogs. Orthotopic segmental small-bowel transplantations (25 to 30% of total small bowel length) were performed in twostages: first a heterotopic segmental small bowel transplantation, followed after 5 to 8 weeks by a second-stage operation during which theheterotopic graft was placed in an orthotopic position and the nativesmall bowel was resected. All dogs received cyclosporine immunosuppression. Control dogs (n=4), subjected to total enterectomy, survived 37.3+/-7.1 days (mean +/- SEM). Recipients of DLA-mismatched small bowelgrafts (n=6) survived 113.2+/-37.0 days, which was a significantly shorter time than dogs with a DLA-matched graft (n=6, 211.5+/-38.8 days, P<0.05). None of the matched allografts was rejected during CsA treatment, whereas four of six mismatched grafts were (P<0.05). The control dogs uniformly showed progressive weight loss, steatorrhea, and hypoalbuminemia. The dogs with DLA-mismatched grafts did not regain initial body weight, whereas animals with DLA-matched grafts recovered preoperative weight after 20 weeks. Both transplanted groups showed near-normal fecal fat excretions and constant serum albumin, cholesterol, and triglyceride levels, whereas serum total protein levels increased during follow-up. We conclude that segmental small bowel transplantation between DLA-matched donor-recipient pairs results in long-term survivorswith an adequate nutritional status. This may have important implications for future living-related small-bowel transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:29:28