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Titolo:
OXYGENATION IN THE RABBIT MYOCARDIUM - ASSESSMENT WITH SUSCEPTIBILITY-DEPENDENT MR-IMAGING
Autore:
ATALAY MK; FORDER JR; CHACKO VP; KAWAMOTO S; ZERHOUNI EA;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,143 MRI BLDG,600 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL & RADIOL SCI BALTIMORE MD 21205
Titolo Testata:
Radiology
fascicolo: 3, volume: 189, anno: 1993,
pagine: 759 - 764
SICI:
0033-8419(1993)189:3<759:OITRM->2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY STIMULATION; BLOOD; HEART; BRAIN; CONSUMPTION; VARIABILITY; CONTRAST; INVIVO; FIELDS; PO2;
Keywords:
HEART; MYOCARDIUM, BLOOD SUPPLY; OXYGEN; MAGNETIC RESONANCE (MR), PULSE SEQUENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Atalay et al., "OXYGENATION IN THE RABBIT MYOCARDIUM - ASSESSMENT WITH SUSCEPTIBILITY-DEPENDENT MR-IMAGING", Radiology, 189(3), 1993, pp. 759-764

Abstract

PURPOSE: To determine the feasibility of using hemoglobin (Kb) desaturation as an indicator of myocardial oxygenation. MATERIALS AND METHODS: High resolution gradient-echo nuclear magnetic resonance (MR) images of isolated, blood-perfused rabbit hearts were obtained at various blood oxygenation levels. The hearts were perfused at 37 degrees C witha Langendorff apparatus modified for nuclear MR imaging. The perfusate contained bovine red blood cells in a cardioplegic solution that eliminated motion artifacts and minimized arteriovenous oxygenation differences. Hb saturation was varied (7%-100%) randomly. Perfusion pressure was continuously monitored, and blood samples were obtained. RESULTS: There was a substantial correlation between image signal intensity in the myocardium and Hb saturation in the blood, believed to be due tosusceptibility effects of the paramagnetic species deoxyhemoglobin. CONCLUSION: Direct and noninvasive determination of regional Kb saturation with susceptibility-dependent MR imaging may provide information regarding regional myocardial O-2 content.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:11:25