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Titolo:
INFLUENCE OF THE RENAL MEDULLARY CIRCULATION ON THE CONTROL OF SODIUM-EXCRETION
Autore:
ROMAN RJ; ZOU AP;
Indirizzi:
MED COLL WISCONSIN,DEPT PHYSIOL,8701 WATERTOWN PLANK RD MILWAUKEE WI 53226
Titolo Testata:
The American journal of physiology
fascicolo: 5, volume: 265, anno: 1993,
parte:, 2
pagine: 180000963 - 180000973
SICI:
0002-9513(1993)265:5<180000963:IOTRMC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERSTITIAL HYDROSTATIC-PRESSURE; PAPILLARY BLOOD-FLOW; VOLUME-EXPANDED RATS; PROXIMAL CONVOLUTED TUBULE; ATRIAL NATRIURETIC PEPTIDE; ANTI-DIURETIC HORMONE; ANGIOTENSIN-II; NITRIC-OXIDE; PERFUSION-PRESSURE; VASA RECTA;
Keywords:
VASA-RECTA; URINE CONCENTRATION AND DILUTION; KIDNEY; RENAL HEMODYNAMICS; RENAL TUBULES; RENAL PAPILLA; HYPERTENSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
111
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Roman e A.P. Zou, "INFLUENCE OF THE RENAL MEDULLARY CIRCULATION ON THE CONTROL OF SODIUM-EXCRETION", The American journal of physiology, 265(5), 1993, pp. 180000963-180000973

Abstract

Although the role of the renal medullary circulation in the control of urinary concentrating ability is well established, its potential influence on tubular sodium reabsorption is not generally recognized. Nearly 30 years ago, changes in the intrarenal distribution of blood flowwere first proposed to contribute to the natriuretic response to volume expansion. However, the lack of reliable methods for studying medullary blood flow limited progress in this area. The recent development of laser-Doppler flowmetry and videomicroscopic techniques for the study of the vasa recta circulation has renewed interest in the role of medullary hemodynamics in the control of sodium reabsorption. Results of these studies indicate that changes in renal medullary hemodynamics alter renal interstitial pressure and the medullary solute gradient and play an important role in the natriuretic response to elevations in renal perfusion pressure, intravenous infusion of saline, and changes in tubular sodium reabsorption produced by vasoactive compounds. What is emerging from these studies is the view that changes in renal medullary hemodynamics represent an important but misunderstood and long-ignored factor in the control of tubular sodium reabsorption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:30:48