Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACQUIRED HYPOGAMMAGLOBULINEMIA AND MULTI FOCAL GRANULOMATOSIS
Autore:
VERGNON JM; GUICHENEZ P; ORIOL P; POULARD G; JAUBERT J; EMONOT A;
Indirizzi:
CHU ST ETIENNE,HOP NORD,SERV PNEUMOL & ONCOL THORAC F-42055 ST ETIENNE 2 FRANCE
Titolo Testata:
Revue des maladies respiratoires
fascicolo: 5, volume: 10, anno: 1993,
pagine: 480 - 482
SICI:
0761-8425(1993)10:5<480:AHAMFG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
FRE
Keywords:
HYPOGAMMAGLOBULINEMIA; GRANULOMATOSIS; SARCOIDOSIS; BRONCHOALVEOLAR LAVAGE; ALVEOLAR PROTEINS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Vergnon et al., "ACQUIRED HYPOGAMMAGLOBULINEMIA AND MULTI FOCAL GRANULOMATOSIS", Revue des maladies respiratoires, 10(5), 1993, pp. 480-482

Abstract

In adult acquired hypogammaglobulinaemia multi focal granulomas have often been described and have regularly led to the hypothesis of an association with sarcoidosis. We present a case of this type in a man aged 29 who was a smoker with a hypoglobulinaemia involving IgG, IgA andIgM and which was discovered following pneumococcal pneumonias. He presented with a significant hepatosplenomegaly and absent cutaneous reactions to T dependant antigens with an elevated ACE activity. Histological examination of the splenectomy specimen and of the liver biopsy showed an infiltration by epithelioid follicles and confluent giant cells without necrosis. The pulmonary studies showed a normal chest radiograph but the bronchial biopsy again found a granulomatous infiltration. The broncho-alveolar lavage was cytologically normal and a very slight and paradoxical reduction of the alveolar immunoglobulins was noted implying either an active intraalveolar concentration of immunoglobulins or a local synthesis. In the light of the few reported cases it seems that the diagnosis of sarcoidosis should be dismissed here in favour of multi focal granulomatosis with hypogammaglobulinaemia. In hypogammaglobulinaemia there is no clinical or biological method (IDR tuberculin, ACE, Kveim, histology) to confirm a superadded diagnosis of sarcoidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:24:13