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Titolo:
SPERMATOGENESIS PROTECTION - MYTH OR REAL ITY
Autore:
JEGOU B; DELACALLE JFV;
Indirizzi:
UNIV RENNES 1,INSERM,CJF 9104,ETUDE REPROD CHEZ MALE GRP F-35042 RENNES FRANCE
Titolo Testata:
Contraception fertilite sexualite
fascicolo: 10, volume: 21, anno: 1993,
pagine: 744 - 748
SICI:
1165-1083(1993)21:10<744:SP-MOR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
FRE
Keywords:
GONADAL PROTECTION; RADIOTHERAPY; CHEMOTHERAPY; GENOTOXICITY; TOXICITY; MALE FERTILITY; TESTIS; MEDROXYPROGESTERONE ACETATE; TESTOSTERONE; CONTRACEPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
B. Jegou e J.F.V. Delacalle, "SPERMATOGENESIS PROTECTION - MYTH OR REAL ITY", Contraception fertilite sexualite, 21(10), 1993, pp. 744-748

Abstract

Cytotoxic agents used in various therapies (anticancer treatments in particular) are known to be very deleterious to male fertility In these situations, both quantitative (oligo and azoospermia) and qualitative alterations of the male reproductive system occur. What are the various possibilities to protect male reproduction? Sperm cryostorage, prior to the beginning of chemotherapy and / or radiotherapy, is one possibility. However this possibility can only be offered to a relatively limited number of patients, due to the fact that the disease itself often causes gonadal abnormalities. Another possibility is the substitution of the most cytotoxic drugs by less deleterious agents, as well as, the reduction of the doses used in the therapeutic regimens. Progress in this field however remains very slow. Therefore, the use of various protective agents appears to be necessary. Of all the agents so fartested (anti-oxydants, GnRH analogs, FSH, steroids), the combination of medroxyprogesterone acetate and testosterone (MPA + T) is the one which has been the most studied both in men (contraception) and in rodents (contraception and protection). From a series of experiments usingMPA + T in male rats, it appears that both qualitative and quantitative protection of fertility can be achieved against chemo- and radiotherapy. Progress in this field should be the prelude of clinical trials. This transfer from animals to men, should result as one of the activities of a pluridisciplinary group supported by INSERM and entitled << Prosperm >>. The dialogue established in this group between researchers and physicians offers new perspectives in the domain of protection of spermatogenesis, at a time when this is most needed. In fact, recentepidemiological studies have revealed the increase incidence of reproductive abnormalities in the human male, which may be caused by environmental factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:38:26