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Titolo:
A PARENT-TWIN STUDY OF PLASMA-LEVELS OF HISTIDINE-RICH GLYCOPROTEIN (HRG)
Autore:
BOOMSMA DI; HENNIS BC; VANWEES AGM; FRANTS RR; KLUFT C;
Indirizzi:
FREE UNIV AMSTERDAM,DEPT PSYCHONOM,DE BOELELAAN 1111 1081 HV AMSTERDAM NETHERLANDS TNO,IVVO,GAUBIUS LAB 2313 AD LEIDEN NETHERLANDS LEIDEN UNIV,DEPT HUMAN GENET 2300 RA LEIDEN NETHERLANDS
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 5, volume: 70, anno: 1993,
pagine: 848 - 851
SICI:
0340-6245(1993)70:5<848:APSOPO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ELEVATION; HIGH-AFFINITY; SERUM; SEQUENCE; PROTEIN; SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.I. Boomsma et al., "A PARENT-TWIN STUDY OF PLASMA-LEVELS OF HISTIDINE-RICH GLYCOPROTEIN (HRG)", Thrombosis and haemostasis, 70(5), 1993, pp. 848-851

Abstract

Histidine- rich glycoprotein (HRG) is a non-enzymatic glycoprotein that acts as a modulator of several plasma proteins involved in coagulation and fibrinolysis. The contributions of genetic and environmental influences to inter-individual variation in plasma levels of HRG were studied in 160 Dutch families consisting of adolescent twin pairs and their parents. Results showed that 69% of the variance in plasma HRG concentrations could be accounted for by genetic factors. Heritability was the same in males and females and in parents and their offspring. There was no association between HRG levels of husband and wife and no evidence was found for the influence of shared family environment on the resemblance between relatives.

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Documento generato il 23/01/20 alle ore 18:13:38