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Titolo:
DIFFERENTIAL EFFECT OF HOST MICROENVIRONMENT AND SYSTEMIC HUMORAL-FACTORS ON THE IMPLANTATION AND THE GROWTH-RATE OF METASTATIC TUMOR IN PARABIOTIC MICE CONSTRUCTED BETWEEN YOUNG AND OLD MICE
Autore:
HIRAYAMA R; TAKEMURA K; NIHEI Z; ICHIKAWA W; TAKAGI Y; MISHIMA Y; UTSUYAMA M; HIROKAWA K;
Indirizzi:
TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PATHOL,ITABASHI KU,35-2 SAKAECHO TOKYO TOKYO JAPAN TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PATHOL,ITABASHI KU TOKYO TOKYO JAPAN TOKYO MED & DENT UNIV,SCH MED,DEPT SURG 2,BUNKYO KU TOKYO TOKYO 113 JAPAN
Titolo Testata:
Mechanism of ageing and development
fascicolo: 3, volume: 71, anno: 1993,
pagine: 213 - 221
SICI:
0047-6374(1993)71:3<213:DEOHMA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-16 MELANOMA; T-CELLS; AGE; CANCER; THYMUS;
Keywords:
METASTASIS; B-16 MELANOMA; AGING; PARABIOSIS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R. Hirayama et al., "DIFFERENTIAL EFFECT OF HOST MICROENVIRONMENT AND SYSTEMIC HUMORAL-FACTORS ON THE IMPLANTATION AND THE GROWTH-RATE OF METASTATIC TUMOR IN PARABIOTIC MICE CONSTRUCTED BETWEEN YOUNG AND OLD MICE", Mechanism of ageing and development, 71(3), 1993, pp. 213-221

Abstract

B16 melanoma cells were injected into the tail vein of young mice, old mice and parabiotic mice constructed between young and old mice, andthe number and shape of pulmonary metastases were compared among three experimental groups. In unpaired mice, the number of metastatic colonies in the lungs was 10-fold larger in young than in old mice. In parabiotic mice, the number in young mice was almost comparable with thatof unpaired young mice, but the number in old mice approached the level of young mice. Metastatic colonies on the pulmonary surface of young mice were mostly nodular in shape, while those of old mice were flatin shape. The shape of colonies reflecting the tumor growth rate did not change in parabiotic old mice in spite of an increase in number. In young parabiotic mice, the large and intermediate colonies decreasedwith a concomitant increase of small ones as compared with unpaired young mice. These results suggest that the implantation of metastatic colonies in the lung is mainly dependent on systemic humoral factors and their growth is mainly dependent on the host local factors in the microenvironment, and distinct age changes of both factors greatly influence the metastatic mode of tumors, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:45:07