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Titolo:
SPECT IMAGING OF DOPAMINE AND SEROTONIN TRANSPORTERS WITH [I-123] BETA-CIT - BINDING-KINETICS IN THE HUMAN BRAIN
Autore:
BRUCKE T; KORNHUBER J; ANGELBERGER P; ASENBAUM S; FRASSINE H; PODREKA I;
Indirizzi:
UNIV VIENNA,NEUROL KLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA CLIN NUCL MED VIENNA AUSTRIA UNIV WURZBURG,DEPT PSYCHIAT W-8700 WURZBURG GERMANY FORSCHUNGSZENTRUM SEIBERSDORF SEIBERSDORF AUSTRIA
Titolo Testata:
Journal of neural transmission
fascicolo: 2, volume: 94, anno: 1993,
pagine: 137 - 146
SICI:
0300-9564(1993)94:2<137:SIODAS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE REUPTAKE SITES; PRIMATE BRAIN; DISEASE; RTI-55; AGE;
Keywords:
DOPAMINE; SEROTONIN; TRANSPORTER; SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY (SPECT); BETA-CIT; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
T. Brucke et al., "SPECT IMAGING OF DOPAMINE AND SEROTONIN TRANSPORTERS WITH [I-123] BETA-CIT - BINDING-KINETICS IN THE HUMAN BRAIN", Journal of neural transmission, 94(2), 1993, pp. 137-146

Abstract

Single photon emission computerized tomography (SPECT) studies in non-human primates have previously shown that the cocaine derivative -2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane ([I-123]beta-CIT) labels dopamine transporters in the striatum and serotonin transporters in the hypothalamus-midbrain area. Here, we report on the regional kinetic uptake of [I-123]beta-CIT in the brain of 4 normal volunteers and 2 patients with Parkinson's disease. In healthy subjects striatal activity increased slowly to reach peak values at about 20 hours post injection. In the hypothalamus-midbrain area peak activities were observed at about 4 hours with a slow decrease thereafter. Low activity was observed in cortical and cerebellar areas. The striatal to cerebellar ratio was about 4 after 5 hours and 9 after 20 hours. In 2 patients with idiopathic Parkinson's disease striatal activity was markedly decreasedwhile the activity in hypothalamus-midbrain areas was only mildly diminished. Uptake into cortical and cerebellar areas appeared to be unchanged in Parkinson's disease. Consequently, in Parkinson's disease thestriatal to cerebellar ratio was decreased to values around 2.5 after20 hours. These preliminary methodological studies suggest that [I-123]beta-CIT is a useful SPECT ligand for studying dopamine and possiblyalso serotonin transporters in the living human brain.

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Documento generato il 17/09/19 alle ore 22:37:45