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Titolo:
NATURALLY-OCCURRING ISOQUINOLINES PERTURB MONOAMINE METABOLISM IN THEBRAIN - STUDIED BY IN-VIVO MICRODIALYSIS
Autore:
MARUYAMA W; NAKAHARA D; DOSTERT P; TAKAHASHI A; NAOI M;
Indirizzi:
NAGOYA INST TECHNOL,DEPT BIOSCI,GOKISO CHO NAGOYA AICHI 466 JAPAN NAGOYA INST TECHNOL,DEPT BIOSCI,GOKISO CHO NAGOYA AICHI 466 JAPAN FARMITALIA CARLO ERBA SPA,RES & DEV,ERBAMONT GRP MILAN ITALY NAGOYA UNIV,SCH MED,DEPT NEUROL NAGOYA AICHI 466 JAPAN NAGOYA UNIV,COLL MED TECHNOL,DEPT PSYCHOL NAGOYA AICHI 464 JAPAN
Titolo Testata:
Journal of neural transmission
fascicolo: 2, volume: 94, anno: 1993,
pagine: 91 - 102
SICI:
0300-9564(1993)94:2<91:NIPMMI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYLISOQUINOLINIUM ION; TYROSINE-HYDROXYLASE; OXIDASE INHIBITORS; PARKINSONS-DISEASE; TETRAHYDROISOQUINOLINE; SALSOLINOL; DOPAMINE; RAT; N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; ENANTIOMERS;
Keywords:
TETRAHYDROISOQUINOLINES; MONOAMINE OXIDASE; CATECHOL-O-METHYL-TRANSFERASE; MONOAMINES; RAT STRIATUM; IN-VIVO MICRODIALYSIS; PARKINSONS DISEASE; ALCOHOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
W. Maruyama et al., "NATURALLY-OCCURRING ISOQUINOLINES PERTURB MONOAMINE METABOLISM IN THEBRAIN - STUDIED BY IN-VIVO MICRODIALYSIS", Journal of neural transmission, 94(2), 1993, pp. 91-102

Abstract

Naturally occurring isoquinolines affected the monoamine metabolism in the rat striatum, as proved by in vivo microdialysis technique. By analysis of monoamines and their metabolites in the dialysate, dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines were found to inhibit monoamine oxidase and catechol-O-methyltransferase activity. 1-Methyl- and ethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline were found to inhibit activity of type A monoamine oxidase most markedly. To compare the structure-activity relationship, corresponding isoquinolines without a catechol structure were also examined. The inhibition by catechol isoquinolines was more manifest than those without a catecholstructure. Among latter isoquinolines, N-methyl-isoquinolinium ion was the most potent inhibitor of monoamine oxidase. In addition, catechol isoquinolines increased monoamine levels in the brain. The number and the site of the methyl group are essentially required for the inhibition of monoamine oxidase and a catechol structure for that of catechol-O-methyl-transferase. These results are discussed in relation to possible involvement of these isoquinolines to the clinical features of some neuro-psychiatric diseases, such as alcoholism or in L-DOPA therapy.

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Documento generato il 31/03/20 alle ore 04:42:02