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Titolo:
IMMUNOCYTOCHEMICAL LOCALIZATION OF CATHEPSIN-D AND CA-125 IN OVARIAN CANCER
Autore:
ATHANASSIADOU P; SAKELLARIOU V; MICHALAS S; PETRAKAKOU E; ATHANASSIADES P; ARAVANTINOS D;
Indirizzi:
UNIV ATHENS,SCH MED,CYTOL LAB,DEPT PATHOL,75 MICRAS ASIAS STR GR-11527 GOUDI ATHENS GREECE ALEXANDRA HOSP,DEPT OBSTET & GYNECOL 1 ATHENS GREECE
Titolo Testata:
International journal of gynaecology and obstetrics
fascicolo: 1, volume: 56, anno: 1997,
pagine: 31 - 37
SICI:
0020-7292(1997)56:1<31:ILOCAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; PROGNOSTIC-SIGNIFICANCE; PROGESTERONE RECEPTORS; ESTROGEN; CELLS;
Keywords:
CATHEPSIN D; CA 125; IMMUNOCYTOCHEMISTRY; OVARIAN; CARCINOMA; PROGNOSTIC FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Athanassiadou et al., "IMMUNOCYTOCHEMICAL LOCALIZATION OF CATHEPSIN-D AND CA-125 IN OVARIAN CANCER", International journal of gynaecology and obstetrics, 56(1), 1997, pp. 31-37

Abstract

Objective: To study the expression of Cathepsin D (Cath D) and CA 125antigens and ER and PR receptors on freshly obtained surgical specimens of ovarian carcinomas and their relationship with menopausal status, tumor histology, primary tumor size and lymph node invasion. Method:The tumors obtained from 100 women were measured and cut in half. Thecut surface of one half was pressed against glass slides which were air dried and stained using the Avidin-Biotin peroxidase method for Cath D and CA 125 antigens. The slides were viewed under the light microscope for the characteristic brown granules in the cytoplasm or nlembrane of the malignant cells. The other half of the tumor was subjected to routine histological examination and part used for the demonstrationof ER and PR receptors. The results were analyzed using chi(2) analysis. Results: Cath D positivity was as common as CA 125 positivity. Cath D positivity is more frequently associated with serous carcinomas than with others. No relationship was observed between ER/PR positivity and Cath D or CA 125 positivity. Conclusion: The high incidence of Cath D positivity makes it a possible complementary method for following up ovarian carcinoma patients especially those who are CA 125 negative. (C) 1997 International Federation of Gynecology and Obstetrics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:00:54