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Titolo:
EXTERNAL IMAGING OF ATHEROSCLEROSIS IN RABBITS USING AN I-123 LABELEDSYNTHETIC PEPTIDE FRAGMENT
Autore:
HARDOFF R; BRAEGELMANN F; ZANZONICO P; HERROLD EM; LEES RS; LEES AM; DEAN RT; LISTERJAMES J; BORER JS;
Indirizzi:
CORNELL UNIV,MED CTR,NEW YORK HOSP,525 E 68TH ST NEW YORK NY 10021 CORNELL UNIV,MED CTR,COLL MED,DEPT MED & RADIOL NEW YORK NY 10021 BOSTON HEART FDN CAMBRIDGE MA 00000
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 11, volume: 33, anno: 1993,
pagine: 1039 - 1047
SICI:
0091-2700(1993)33:11<1039:EIOAIR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; FAT-FED RABBITS; ARTERIAL-WALL; APOLIPOPROTEIN-B; NONHUMAN PRIMATE; HUMAN AORTA; HYPERCHOLESTEROLEMIA; ACCUMULATION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R. Hardoff et al., "EXTERNAL IMAGING OF ATHEROSCLEROSIS IN RABBITS USING AN I-123 LABELEDSYNTHETIC PEPTIDE FRAGMENT", Journal of clinical pharmacology, 33(11), 1993, pp. 1039-1047

Abstract

The oligopeptide fragment of apolipoprotein B, SP-4, has demonstratedpronounced uptake in the healing edges of balloon-injured rabbit aortic endothelium. To assess I-123-labeled SP-4 for identification of atherosclerotic plaques by gamma camera imaging, 14 Watanabe heritable hyperlipidemic (WHHL) and 5 normal rabbits were imaged 5 minutes and 12 and 24 hours after intravenous injection of I-123-SP-4. In addition, two WHHL and two normal rabbits were injected with I-125-SP-4 for autoradiography. Twelve of the 14 WHHL, but none of the normal, rabbits hadvisually apparent focal radioiodine accumulation in the region of theaorta. Focus-to-lung and focus-to-heart count ratios were 2.4 +/- 1.3and 1.0 +/- 0.4, respectively. Five of the visually positive WHHL rabbits were reimaged 4 and 8 weeks later with I-123-NaI and I-123-SP-2 (an apo E peptide), respectively, as negative controls. Perceptible, but faint, aortic localization of I-123-NaI and of I-123-SP-2 was seen in only one animal each. The distributions of atherosclerotic lesions on photographs of the opened WHHL aortas and of film blackening on I-125-SP-4 autoradiograms were identical. In contrast, the two normal rabbit aortas did not exhibit plaques on photographs or film blackening onautoradiograms. Thus, in an animal model closely simulating human atherosclerotic disease, SP-4 localizes specifically in aortic atherosclerotic lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:25:01