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Titolo:
SUBACUTE TOXICITY OF PIPERONYL BUTOXIDE IN ICR MICE
Autore:
FUJITANI T; TANAKA T; HASHIMOTO Y; YONEYAMA M;
Indirizzi:
TOKYO METROPOLITAN RES LAB PUBL HLTH,DEPT TOXICOL,SHINJUKU KU,3-24-1 HYAKUNINCHO TOKYO 169 JAPAN
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 83, anno: 1993,
pagine: 93 - 100
SICI:
0300-483X(1993)83:1-3<93:STOPBI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
F344 RATS;
Keywords:
FOOD-ADDITIVE; MICE; PIPERONYL BUTOXIDE; PESTICIDE SYNERGIST; SUBACUTE; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
T. Fujitani et al., "SUBACUTE TOXICITY OF PIPERONYL BUTOXIDE IN ICR MICE", Toxicology, 83(1-3), 1993, pp. 93-100

Abstract

Piperonyl butoxide, ethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene, is a pesticide synergist. ICR mice of both sexes were maintained on diet containing 0, 0.1, 0.3 or 0.9% of piperonyl butoxide for 20 days. At the end of the experimental period, they were necropsied. Selectedorgans were weighed and serum chemistries were analyzed. In male and female mice of the 0.9% group, body weight, kidney and spleen weight were depressed in comparison to those of control group. Liver weight ofthe 0.3 and 0.9% group of both sexes were significantly higher than those of control group. Mice of the 0.9% group of both sexes had increased serum levels of cholesterol, total protein, gamma-glutamyl transpeptidase. Histological examination of livers from mice of the 0.9% group by light microscopy showed enlarged hepatocytes, anisonucleosis and single cell necrosis. The results indicated that subacute toxicity of piperonyl butoxide in ICR mice was directed primarily at liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:47:40