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Titolo:
INTERLEUKIN-4 AND INTERLEUKIN-10 SYNERGIZE TO INHIBIT CELL-MEDIATED-IMMUNITY IN-VIVO
Autore:
POWRIE F; MENON S; COFFMAN RL;
Indirizzi:
DNAX RES INST MOLEC & CELLULAR BIOL INC,901 CALIF AVE PALO ALTO CA 94304
Titolo Testata:
European Journal of Immunology
fascicolo: 11, volume: 23, anno: 1993,
pagine: 3043 - 3049
SICI:
0014-2980(1993)23:11<3043:IAISTI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; TUMOR-NECROSIS-FACTOR; IFN-GAMMA; INTERFERON-GAMMA; CYTOKINE PRODUCTION; TH1 CLONES; CUTANEOUS LEISHMANIASIS; MONOCLONAL-ANTIBODIES; IL-10; RESPONSES;
Keywords:
INTERLEUKIN-4; INTERLEUKIN-10; SYNERGY; CELL-MEDIATED IMMUNITY; IMMUNOREGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
F. Powrie et al., "INTERLEUKIN-4 AND INTERLEUKIN-10 SYNERGIZE TO INHIBIT CELL-MEDIATED-IMMUNITY IN-VIVO", European Journal of Immunology, 23(11), 1993, pp. 3043-3049

Abstract

The lack of cell-mediated (Th1-like) immunity that is often associated with strong humoral immune responses is thought to be due in part tothe inhibition of Th1 effector function by the Th2-derived cytokine interleukin-10 (IL-10). This hypothesis, however. is based entirely on results from in vitro studies, wherein IL-10 has been shown to inhibitTh1 cytokine synthesis. In this study we have compared the regulatoryeffects of both IL-4 and IL-10 on the development of a more complex Th1 effector function in vivo, the development of delayed-type hypersensitivity (DTH) to Leishmania major in mice immune to Leishmania. The results revealed two findings unexpected from in vitro studies with Th1clones. First, optimal inhibition of the DTH response (up to 70%), assessed by footpad swelling and leukocytic infiltration, required the combination of IL-4 and IL-10, indicating that these two activities synergized to inhibit DTH reactivity. Second, IL-4 inhibited interferon-gamma (IFN-gamma) production by lymph node cells draining the site of antigen challenge as well as did IL-10. The combination of both cytokines was no more effective than either alone. The mechanism by which IL-4 and IL-10 acted to inhibit DTH responses did not appear to be through inhibition of IFN-gamma or tumor necrosis factor production as treatment with antibodies which neutralized these activities failed to inhibit DTH responses. Inhibition of the DTH with IL-4 and IL-10 is the most effective specific regulator of DTH responses reported and the onlyone capable of modulating tuberculin DTH. These data establish IL-4 and IL-10 as potent inhibitors of Th1 effector function in vivo and suggest their utility in controlling deleterious Th1-mediated inflammatory responses such as occur in some infectious and autoimmune diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:53:00